Zou Rong, Mu De-Zhi
Department of Pediatrics, West China Second Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2016 Sep;18(9):915-920. doi: 10.7499/j.issn.1008-8830.2016.09.024.
Hypoxic-ischemic encephalopathy (HIE) in neonates is the brain injury caused by perinatal asphyxia or hypoxia and is a major cause of death in neonates and nervous system dysfunction in infants and young children. Although to a certain degree, mild hypothermia therapy reduces the mortality of infants with moderate to severe HIE, it cannot achieve the expected improvements in nervous system dysfunction. Hence, it is of vital importance to search for effective therapeutic methods for HIE. The search for more therapies and better preventive measures based on the pathogenesis of HIE has resulted in much research. As an important link in the course of HIE, energy failure greatly affects the development and progression of HIE. This article reviews the research advances in the treatment and prevention of energy failure in the course of HIE.
新生儿缺氧缺血性脑病（HIE）是由围产期窒息或缺氧引起的脑损伤，是新生儿死亡以及婴幼儿神经系统功能障碍的主要原因。尽管轻度低温治疗在一定程度上降低了中重度HIE患儿的死亡率，但无法实现预期的神经系统功能障碍改善效果。因此，寻找HIE的有效治疗方法至关重要。基于HIE发病机制寻找更多治疗方法和更好的预防措施引发了大量研究。能量衰竭作为HIE病程中的一个重要环节，极大地影响了HIE的发展和进程。本文综述了HIE病程中能量衰竭治疗和预防的研究进展。
