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近期有关围生期常见治疗方法对后代神经发育影响的研究。

Recent research on the effect of common treatments given in the perinatal period on neurodevelopment in offspring.

机构信息

Department of Neonatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2022 Mar 15;24(3):332-338. doi: 10.7499/j.issn.1008-8830.2111002.

DOI:10.7499/j.issn.1008-8830.2111002
PMID:35351267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8974644/
Abstract

The perinatal period is the key period for the development of brain and central nervous system, and different events in this period will have a profound influence on brain development. Glucocorticoids, antibiotics, magnesium sulfate, caffeine, pulmonary surfactant, and mild hypothermia treatment are commonly used drugs or treatment methods in the perinatal period and are closely associated with the prognosis of neonatal neurodevelopment. This article reviews the latest research on the effect of perinatal treatments on neonatal neurodevelopment, so as to provide a reference for clinical decision making.

摘要

围产期是大脑和中枢神经系统发育的关键时期,这一时期的不同事件都会对大脑发育产生深远影响。围产期常用的药物或治疗方法有糖皮质激素、抗生素、硫酸镁、咖啡因、肺表面活性剂、亚低温治疗等,这些方法均与新生儿神经发育预后密切相关。本文就围产期治疗对新生儿神经发育的影响的最新研究作一综述,以期为临床决策提供参考。

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本文引用的文献

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Apnoea of Prematurity and Neurodevelopmental Outcomes: Current Understanding and Future Prospects for Research.早产呼吸暂停与神经发育结局:当前认识与未来研究展望
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Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment following Early Erythropoietin among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection Trial.在早产儿促红细胞生成素神经保护试验中,弥散张量成像变化不影响极早产儿早期使用促红细胞生成素后的长期神经发育。
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The Neuroprotective Efficacy of Postnatal Magnesium Sulfate in Term or Near-Term Infants With Moderate-to-Severe Birth Asphyxia.产后硫酸镁对足月或近足月中重度出生窒息婴儿的神经保护作用
Cureus. 2021 Aug 2;13(8):e16826. doi: 10.7759/cureus.16826. eCollection 2021 Aug.
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Child growth and neurodevelopment after maternal antenatal antibiotic treatment.母亲产前抗生素治疗后儿童的生长和神经发育。
Arch Dis Child. 2022 Apr;107(4):323-328. doi: 10.1136/archdischild-2021-322043. Epub 2021 Sep 3.
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Cerebral Palsy in Very Preterm Infants: A Nine-Year Prospective Study in a French Population-Based Tertiary Center.极早产儿脑瘫:法国基于人群的三级中心 9 年前瞻性研究。
J Pediatr. 2021 Oct;237:183-189.e6. doi: 10.1016/j.jpeds.2021.06.018. Epub 2021 Jun 16.
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Prophylactic Erythropoietin for Neuroprotection in Very Preterm Infants: A Meta-Analysis Update.预防性促红细胞生成素对极早产儿的神经保护作用:一项Meta分析更新
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7
Study protocol: baby-OSCAR trial: Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial.研究方案:婴儿-Oscar 试验:选择性早期治疗早产儿动脉导管未闭的结局,一项多中心、盲法、随机、安慰剂对照的平行组试验。
BMC Pediatr. 2021 Feb 26;21(1):100. doi: 10.1186/s12887-021-02558-7.
8
Nitric oxide and sex differences in dendritic branching and arborization.一氧化氮与树突分支和分支形态的性别差异。
J Neurosci Res. 2021 May;99(5):1390-1400. doi: 10.1002/jnr.24789. Epub 2021 Feb 3.
9
Trial of paracetamol for premature newborns: five-year follow-up.对早产儿使用扑热息痛的试验:5 年随访。
J Matern Fetal Neonatal Med. 2022 Dec;35(25):5210-5212. doi: 10.1080/14767058.2021.1875444. Epub 2021 Jan 21.
10
Antenatal corticosteroid administration and early school age child development: A regression discontinuity study in British Columbia, Canada.产前皮质类固醇给药与儿童早期学校年龄发育:加拿大不列颠哥伦比亚的回归不连续研究。
PLoS Med. 2020 Dec 7;17(12):e1003435. doi: 10.1371/journal.pmed.1003435. eCollection 2020 Dec.