van der Weiden Robin M F, Helmerhorst Frans M, Eriksson Tomas
Department of Obsterics and Gynaecology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
Department of Obstetrics and Gynaecology, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, The Netherlands.
BMJ Case Rep. 2016 Sep 21;2016:bcr2016216378. doi: 10.1136/bcr-2016-216378.
Aggression in patients with autism spectrum disorder (ASD) presents an important therapeutic challenge. Conventional treatment appears to be inadequate in a number of cases. The occurrence of severe aggressive symptoms since the inception of adolescence in a male patient with ASD suggested a hormonal influence by androgens. Conventional treatment with antipsychotic and antiepileptic drugs and benzodiazepines was ineffective. A subcutaneous long-acting gonadotropin-releasing hormone agonist (GnRH agonist) injection was given on a monthly basis resulting in a substantial improvement in his aggressive behaviour and renewed socialisation.
自闭症谱系障碍（ASD）患者的攻击行为是一项重要的治疗挑战。在许多情况下，传统治疗似乎并不充分。一名患有ASD的男性患者自青春期开始就出现严重的攻击症状，这表明雄激素存在激素影响。使用抗精神病药物、抗癫痫药物和苯二氮䓬类药物进行的传统治疗无效。每月皮下注射一次长效促性腺激素释放激素激动剂（GnRH激动剂）后，其攻击行为有了显著改善，社交能力也得以恢复。
