Eriksson Tomas
The Biological Psychiatry Research Group, Department of Clinical Sciences, Malmö, Lund University, MAS University Hospital, Malmö, Sweden.
Int Clin Psychopharmacol. 2007 Jan;22(1):57-61. doi: 10.1097/01.yic.0000224793.51900.cb.
Some case reports have shown that patients suffering from obsessive-compulsive disorder can be effectively treated with anti-androgenic pharmacological agents with various modes of action. The most effective group of such agents is the long-acting analogues of the gonadotropin-releasing hormone. This investigation was undertaken in order to further elucidate the possibility of using such powerful anti-androgenic agents in the treatment of obsessive-compulsive disorder. Six male patients, all suffering from therapy-resistant obsessive-compulsive disorder, were included in a 48 weeks open-label trial of the long-acting GnRH-analogue triptorelin. Every other week, the patients rated the severity of obsessive-compulsive disorder symptoms by means of a visual analogue scale. During the course of the trial, five out of six patients experienced a considerable improvement. The finding gives further support to the contention that anti-androgenic agents are effective in the treatment of obsessive-compulsive disorder.
一些病例报告表明，患有强迫症的患者可以用具有不同作用方式的抗雄激素药理学药物进行有效治疗。这类药物中最有效的一组是促性腺激素释放激素的长效类似物。进行这项研究是为了进一步阐明使用这类强效抗雄激素药物治疗强迫症的可能性。六名男性患者均患有难治性强迫症，他们参与了长效促性腺激素释放激素类似物曲普瑞林的48周开放标签试验。患者每隔一周通过视觉模拟量表对强迫症症状的严重程度进行评分。在试验过程中，六名患者中有五名病情有显著改善。这一发现进一步支持了抗雄激素药物对治疗强迫症有效的观点。
