接受慢性抗肿瘤坏死因子-α治疗的患者感染Q热的风险
Q Fever Risk in Patients Treated with Chronic Antitumor Necrosis Factor-Alpha Therapy.
作者信息
Hirsch Julianna, Astrahan Anna, Odeh Majed, Elias Nizar, Rosner Itzhak, Rimar Doron, Kaly Lisa, Rozenbaum Michael, Boulman Nina, Slobodin Gleb
机构信息
Bruce and Ruth Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Department of Internal Medicine A, Bnai Zion Medical Center, Haifa, Israel.
出版信息
Case Rep Infect Dis. 2016;2016:4586150. doi: 10.1155/2016/4586150. Epub 2016 Aug 30.
Abstract
Q fever is a zoonotic bacterial disease caused by Coxiella burnetii. Tumor necrosis factor-alpha (TNF-α) plays a pivotal role in the defense against infection with this Gram-negative coccobacillus. Theoretically, patients who are treated with anti-TNF-α medications are at risk for developing chronic Q fever. We present two patients who developed Q fever while being treated with anti-TNF-α agents and discuss the significance of timely diagnosis of C. burnetii infection in these patients.
摘要
Q热是一种由伯氏考克斯体引起的人畜共患细菌性疾病。肿瘤坏死因子-α（TNF-α）在抵御这种革兰氏阴性球杆菌感染中起关键作用。理论上，接受抗TNF-α药物治疗的患者有发生慢性Q热的风险。我们报告了两名在接受抗TNF-α药物治疗期间发生Q热的患者，并讨论了及时诊断这些患者伯氏考克斯体感染的意义。
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