Katukuri Goutham Reddy, Maddala Raja Naga Mahesh, Ramamoorthi Kusugodlu, Hande Manjunatha
Junior Resident, Department of General Medicine, Kasturba Medical College, Kasturba Hospital , Manipal, Udupi, Karnataka, India .
Assistant Professor, Department of General Medicine, Kasturba Medical College, Kasturba Hospital , Manipal, Udupi, Karnataka, India .
J Clin Diagn Res. 2016 Aug;10(8):OD10-1. doi: 10.7860/JCDR/2016/19694.8316. Epub 2016 Aug 1.
Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K metabolism resulting in hypoprothombinemia. We report a case of cefoperazone induced coagulopathy manifesting as gastrointestinal bleeding. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient's coagulation function disorder and her use of the suspect drug.
头孢哌酮是一种β-内酰胺类抗生素,常用于治疗各种革兰氏阳性和革兰氏阴性感染。头孢哌酮的化学结构包含一个N-甲基硫代四唑侧链,该侧链可抑制维生素K代谢,导致低凝血酶原血症。我们报告一例头孢哌酮引起的凝血病,表现为胃肠道出血。Naranjo评估得分为5分,表明患者的凝血功能障碍与其使用可疑药物之间可能存在关联。