线粒体外膜电压诱导电导增加的动力学
Kinetics of voltage-induced conductance increases in the outer mitochondrial membrane.
作者信息
Kinnally K W, Tedeschi H, Mannella C A, Frisch H L
机构信息
Department of Biological Sciences, State University of New York, Albany 12222.
出版信息
Biophys J. 1989 Jun;55(6):1205-13. doi: 10.1016/S0006-3495(89)82916-9.
Abstract
The kinetics of the increase in conductance in the outer mitochondrial membrane induced by patch-clamping at various negative potentials (pipette inside negative) are reported. The changes are biphasic, a rapid increase is followed by a slowly developing larger change. The results can be predicted by a model in which an initial activation of channels is followed by their assembly into highly conducting channels. The model suggests that five to seven activated subunits form each high-conductance channel.
摘要
报道了在不同负电位（移液管内为负）下通过膜片钳技术诱导线粒体外膜电导增加的动力学过程。这种变化是双相的，先是快速增加，随后是缓慢发展的更大变化。这些结果可以通过一个模型来预测，在该模型中，通道首先被激活，然后组装成高电导通道。该模型表明，每个高电导通道由五到七个被激活的亚基组成。
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