从中华青牛胆中分离得到的两种新克罗烷二萜。

Two New Clerodane Diterpenes from Tinospora sagittata.

作者信息

Li Guanhua, Ding Wenbing, Wan Fanghao, Li Youzhi

机构信息

College of Plant Protection, Hunan Agricultural University, Changsha 410128, China.

Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China.

出版信息

Molecules. 2016 Sep 19;21(9):1250. doi: 10.3390/molecules21091250.

DOI:10.3390/molecules21091250

PMID:27657021

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6274121/

Abstract

Two new clerodane-type diterpenes, tinosporins C () and tinosporins D () were isolated from the stems of (Oliv.), together with three known ones, columbin (), tinophylloloside (), and tinospinoside D (). The structures of these compounds were determined on the basis of spectroscopic data interpretation, with that of the absolute configuration of compound was assigned by experimental and calculated ECD spectra. The cytotoxicity and α-glucosidase inhibitory activities of isolated compounds were evaluated in vitro.

摘要

从青牛胆（Oliv.）的茎中分离出两种新的克罗烷型二萜，青牛胆素C（）和青牛胆素D（），以及三种已知的化合物，哥伦比亚苷（）、青牛胆叶苷（）和青牛胆刺苷D（）。这些化合物的结构通过光谱数据解析确定，化合物的绝对构型通过实验和计算的电子圆二色光谱确定。对分离得到的化合物进行了体外细胞毒性和α-葡萄糖苷酶抑制活性评价。