Key Laboratory of Ethnic Medicine Resource Chemistry, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650031, China.
Molecules. 2010 Nov 16;15(11):8360-5. doi: 10.3390/molecules15118360.
A novel 18-nor-clerodane diterpenoid named sagitone (1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (2), palmatoside C (3), fibleucin (4), tinophylloloside (5) and epitinophylloloside (6). The structure of the new compound 1 was determined based on MS, IR, 1D and 2D NMR spectral data. The compounds 1-6 did not show significant cytotoxic activity against cancer cell lines K562 and HL-60.
从云南产三叶崖爬藤干根的 95%乙醇提取物中分离得到一个新的 18-降- clerodane 二萜类化合物 sagitone（1），并与五个已知的二萜类化合物 columbin（2）、palmatoside C（3）、fibleucin（4）、tinophylloloside（5）和 epitinophylloloside（6）一起分离得到。根据 MS、IR、1D 和 2D NMR 光谱数据确定了新化合物 1 的结构。化合物 1-6 对 K562 和 HL-60 癌细胞系没有明显的细胞毒性活性。
