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绝经前后女性白细胞组成的差异以及明显的性别二态性。

Difference in Leukocyte Composition between Women before and after Menopausal Age, and Distinct Sexual Dimorphism.

作者信息

Chen Yequn, Zhang Yanhong, Zhao Guojun, Chen Chang, Yang Peixuan, Ye Shu, Tan Xuerui

机构信息

First Affiliated Hospital of Shantou University Medical College, Shantou, China.

Shantou University Medical College, Shantou, China.

出版信息

PLoS One. 2016 Sep 22;11(9):e0162953. doi: 10.1371/journal.pone.0162953. eCollection 2016.

Abstract

There are sex differences in many inflammatory and immune diseases, and the differences tend to diminish after menopause. The underlying reasons are unclear, but sex hormone levels are likely to be an important factor. Blood leukocyte count and composition provide an indicator of the inflammatory and immune status of an individual. We performed a cross-sectional analysis of blood leukocyte data from 46,879 individuals (26,212 men and 20,667 women, aged 18 to 93 years) who underwent a routine health checkup. In women aged around 50 years, neutrophil percentage (NE%) dropped whilst lymphocyte percentage (LY%) rose. Accordingly, women before age 50 had significantly higher NE%, lower LY%, and higher neutrophil-to-lymphocyte ratio (NLR) than women of 51-70 years of age (p = 1.35×10-82, p = 5.32×10-100, and p = 1.25×10-26, respectively). In age groups of <50 years, women had higher NE%, lower LY% and higher NLR than men (p = 1.82×10-206, p = 1.46×10-69, and p = 2.30×10-118, respectively), whereas in age groups of >51 years, it was the reverse (p = 1.92×10-15, p = 1.43×10-84, and p = 1.51×10-48, respectively). These results show that blood leukocyte composition differs between women before and after menopausal age, with distinct sexual dimorphism.

摘要

许多炎症和免疫疾病存在性别差异,且这些差异在绝经后往往会减小。其潜在原因尚不清楚,但性激素水平可能是一个重要因素。血液白细胞计数和组成可反映个体的炎症和免疫状态。我们对46879名(26212名男性和20667名女性,年龄在18至93岁之间)接受常规健康检查的个体的血液白细胞数据进行了横断面分析。在50岁左右的女性中,中性粒细胞百分比(NE%)下降,而淋巴细胞百分比(LY%)上升。因此,50岁以下的女性比51至70岁的女性具有显著更高的NE%、更低的LY%和更高的中性粒细胞与淋巴细胞比值(NLR)(分别为p = 1.35×10-82、p = 5.32×10-100和p = 1.25×10-26)。在<50岁的年龄组中,女性的NE%更高、LY%更低且NLR更高,高于男性(分别为p = 1.82×10-206、p = 1.46×10-69和p = 2.30×10-118),而在>51岁的年龄组中则相反(分别为p = 1.92×10-15、p = 1.43×10-84和p = 1.51×10-48)。这些结果表明,绝经前后女性的血液白细胞组成不同,存在明显的性别二态性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d566/5033487/6bfef373c24d/pone.0162953.g001.jpg

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