Department of Cardiology, Renmin Hospital of Wuhan University, China.
Department of Cardiology, Zhongnan Hospital of Wuhan University, China.
Atherosclerosis. 2014 May;234(1):206-13. doi: 10.1016/j.atherosclerosis.2014.03.003. Epub 2014 Mar 14.
The aim of this study was to investigate whether neutrophil to lymphocyte ratio (NLR) was an independent predictor for all-cause mortality or cardiovascular events in patients undergoing angiography or cardiac revascularization with observational studies by meta-analysis.
Pubmed and Embase were searched without language restrictions for cohort studies published prior to November 2013. Citations were independently screened by 2 authors, and those meeting the inclusion criteria defined a priori were retained. Data on authors, year of publication, location, target participant, comparison of NLR, outcome assessment, number of event and sample size, duration and statistical adjustments were abstracted.
Eight studies were identified that reported on all-cause mortality and five studies were identified that reported on cardiovascular events. The pooled relative risk (RR) of all-cause mortality was 2.33 (95% CI 1.88-2.88) and the RR of cardiovascular events was 1.89 (95% CI 1.42, 2.52) comparing the highest with the lowest category of NLR.
The meta-analysis indicates that NLR is a predictor of all-cause mortality and cardiovascular events. Further well-designed trials are warranted to confirm this association.
本研究旨在通过荟萃分析观察性研究，探讨中性粒细胞与淋巴细胞比值（NLR）是否为接受血管造影或心脏血运重建术患者全因死亡率或心血管事件的独立预测因素。
在没有语言限制的情况下，检索 Pubmed 和 Embase 数据库，以获取截止到 2013 年 11 月发表的队列研究。由两位作者独立筛选文献，并保留那些符合事先定义的纳入标准的文献。提取作者、出版年份、地点、目标参与者、NLR 比较、结局评估、事件数量和样本量、持续时间和统计调整等数据。
确定了 8 项关于全因死亡率的研究和 5 项关于心血管事件的研究。与 NLR 最低组相比，最高组的全因死亡率的合并相对风险（RR）为 2.33（95%CI 1.88-2.88），心血管事件的 RR 为 1.89（95%CI 1.42-2.52）。
荟萃分析表明，NLR 是全因死亡率和心血管事件的预测因子。需要进一步精心设计的试验来证实这种关联。
