Glauser Dominique A, Goodman Miriam B
Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland.
Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA.
Curr Opin Neurobiol. 2016 Dec;41:92-98. doi: 10.1016/j.conb.2016.09.006. Epub 2016 Sep 19.
Adapting behavior to thermal cues is essential for animal growth and survival. Indeed, each and every biological and biochemical process is profoundly affected by temperature and its extremes can cause irreversible damage. Hence, animals have developed thermotransduction mechanisms to detect and encode thermal information in the nervous system and acclimation mechanisms to finely tune their response over different timescales. While temperature-gated TRP channels are the best described class of temperature sensors, recent studies highlight many new candidates, including ionotropic and metabotropic receptors. Here, we review recent findings in vertebrate and invertebrate models, which highlight and substantiate the role of new candidate molecular thermometers and reveal intracellular signaling mechanisms implicated in thermal acclimation at the behavioral and cellular levels.
使行为适应热线索对动物的生长和生存至关重要。事实上，每一个生物和生化过程都受到温度的深刻影响，温度极端变化会造成不可逆转的损害。因此，动物已经进化出热转导机制来在神经系统中检测和编码热信息，以及适应机制来在不同时间尺度上微调它们的反应。虽然温度门控的瞬时受体电位（TRP）通道是描述得最为清楚的一类温度传感器，但最近的研究突出了许多新的候选者，包括离子otropic和代谢型受体。在这里，我们综述了脊椎动物和无脊椎动物模型中的最新发现，这些发现突出并证实了新候选分子温度计的作用，并揭示了在行为和细胞水平上与热适应有关的细胞内信号传导机制。
