在分子水平上可视化的真核生物转录起始机制。
Eukaryotic transcription initiation machinery visualized at molecular level.
作者信息
Han Yan, He Yuan
机构信息
a Department of Molecular Biosciences , Northwestern University , Evanston , IL , USA.
出版信息
Transcription. 2016 Oct 19;7(5):203-208. doi: 10.1080/21541264.2016.1237150.
Abstract
The structures of RNA Polymerase (Pol) II pre-initiation complexes (PIC) have recently been determined at near-atomic resolution, elucidating unprecedented mechanistic details of promoter opening during transcription initiation. The key structural features of promoter opening are summarized here. Structural knowledge of Pol I and III PIC is also briefly discussed.
摘要
RNA聚合酶（Pol）II预起始复合物（PIC）的结构最近已在近原子分辨率下确定，阐明了转录起始过程中启动子开放前所未有的机制细节。本文总结了启动子开放的关键结构特征。还简要讨论了Pol I和III PIC的结构知识。
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2
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3
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4
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