Chen Meng, Yang Chengmin, Sui Chun, Jin Yue, Wei Jianhe
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
PLoS One. 2016 Sep 22;11(9):e0162691. doi: 10.1371/journal.pone.0162691. eCollection 2016.
Salvia miltiorrhiza Bunge is an important medicinal plant used for the treatment of cardiovascular disease. Intraspecific hybridization between a male sterile line and inbred lines was followed by 39 F1 crossings. Cultivars "Zhongdanyaozhi No. 1" (ZD1) and "Zhongdanyaozhi No. 2" (ZD2) were obtained. In 2012 and 2013 tests in Beijing, the two cultivars were compared with three widely accepted types, SDCK, SXCK and HNCK from Shandong, Shanxi and Henan provinces. The yield of ZD1 and ZD2 exceeded the three CKs by more than 48.2% and 39.2%, respectively; the composition of the two hybrid cultivars was similar to the control, although the content of some compounds varied to some extent. The content of salvianolic acid B and tanshinone II A of both ZD1 and ZD2 could measure up the requirement of Chinese Pharmacopoeia. The former showed no obvious advantage than the three CKs, while the later's tanshinone II A was 29.6% higher than the three CKs. Taken together, ZD1 is a high yielding and thick-root-type cultivar which is suitable for decoction pieces; while ZD2 is suitable for component especially lipophilic component extraction. ZD1 and ZD2 reported here are the first cultivars obtained by the hybridization of S. miltiorrhiza.
丹参是一种用于治疗心血管疾病的重要药用植物。利用雄性不育系与自交系进行种内杂交，随后进行了39次F1杂交。获得了品种“中丹药植1号”（ZD1）和“中丹药植2号”（ZD2）。在2012年和2013年于北京进行的试验中，将这两个品种与来自山东、山西和河南的三种广泛认可的类型SDCK、SXCK和HNCK进行了比较。ZD1和ZD2的产量分别比三个对照高出48.2%以上和39.2%；两个杂交品种的成分与对照相似，尽管某些化合物的含量有一定程度的变化。ZD1和ZD2的丹酚酸B和丹参酮II A含量均符合《中国药典》的要求。前者与三个对照相比没有明显优势，而后者的丹参酮II A比三个对照高出29.6%。综上所述，ZD1是一个高产且根粗壮型的品种，适合作为饮片；而ZD2适合用于成分提取尤其是亲脂性成分的提取。这里报道的ZD1和ZD2是通过丹参杂交获得的首批品种。
