使用分层交错T1映射(STONE)序列对天然心肌T1映射的 spoiled梯度回波成像和稳态自由进动成像进行比较。

Comparison of spoiled gradient echo and steady-state free-precession imaging for native myocardial T1 mapping using the slice-interleaved T1 mapping (STONE) sequence.

作者信息

Jang Jihye, Bellm Steven, Roujol Sébastien, Basha Tamer A, Nezafat Maryam, Kato Shingo, Weingärtner Sebastian, Nezafat Reza

机构信息

Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

Department of Computer Science, Technical University of Munich, Munich, Germany.

出版信息

NMR Biomed. 2016 Oct;29(10):1486-96. doi: 10.1002/nbm.3598.

Abstract

Cardiac T1 mapping allows non-invasive imaging of interstitial diffuse fibrosis. Myocardial T1 is commonly calculated by voxel-wise fitting of the images acquired using balanced steady-state free precession (SSFP) after an inversion pulse. However, SSFP imaging is sensitive to B1 and B0 imperfection, which may result in additional artifacts. A gradient echo (GRE) imaging sequence has been used for myocardial T1 mapping; however, its use has been limited to higher magnetic field to compensate for the lower signal-to-noise ratio (SNR) of GRE versus SSFP imaging. A slice-interleaved T1 mapping (STONE) sequence with SSFP readout (STONE-SSFP) has been recently proposed for native myocardial T1 mapping, which allows longer recovery of magnetization (>8 R-R) after each inversion pulse. In this study, we hypothesize that a longer recovery allows higher SNR and enables native myocardial T1 mapping using STONE with GRE imaging readout (STONE-GRE) at 1.5T. Numerical simulations and phantom and in vivo imaging were performed to compare the performance of STONE-GRE and STONE-SSFP for native myocardial T1 mapping at 1.5T. In numerical simulations, STONE-SSFP shows sensitivity to both T2 and off resonance. Despite the insensitivity of GRE imaging to T2 , STONE-GRE remains sensitive to T2 due to the dependence of the inversion pulse performance on T2 . In the phantom study, STONE-GRE had inferior accuracy and precision and similar repeatability as compared with STONE-SSFP. In in vivo studies, STONE-GRE and STONE-SSFP had similar myocardial native T1 times, precisions, repeatabilities and subjective T1 map qualities. Despite the lower SNR of the GRE imaging readout compared with SSFP, STONE-GRE provides similar native myocardial T1 measurements, precision, repeatability, and subjective image quality when compared with STONE-SSFP at 1.5T.

摘要

心脏T1 mapping可实现对间质弥漫性纤维化的无创成像。心肌T1通常通过在施加反转脉冲后,对使用平衡稳态自由进动(SSFP)采集的图像进行体素级拟合来计算。然而,SSFP成像对B1和B0的不完善敏感,这可能会导致额外的伪影。梯度回波(GRE)成像序列已用于心肌T1 mapping;然而,其应用仅限于较高磁场,以补偿GRE与SSFP成像相比更低的信噪比(SNR)。最近提出了一种具有SSFP读出的分层交错T1 mapping(STONE)序列(STONE-SSFP)用于天然心肌T1 mapping,该序列允许在每个反转脉冲后有更长的磁化恢复时间(>8个R-R间期)。在本研究中,我们假设更长的恢复时间可实现更高的SNR,并能够在1.5T场强下使用具有GRE成像读出的STONE(STONE-GRE)进行天然心肌T1 mapping。进行了数值模拟、体模和体内成像,以比较STONE-GRE和STONE-SSFP在1.5T场强下进行天然心肌T1 mapping的性能。在数值模拟中,STONE-SSFP对T2和失谐均敏感。尽管GRE成像对T2不敏感,但由于反转脉冲性能对T2的依赖性,STONE-GRE对T2仍敏感。在体模研究中,与STONE-SSFP相比,STONE-GRE的准确性和精密度较差,但重复性相似。在体内研究中,STONE-GRE和STONE-SSFP的心肌天然T1时间、精密度、重复性和主观T1 map质量相似。尽管与SSFP相比,GRE成像读出的SNR较低,但在1.5T场强下,与STONE-SSFP相比,STONE-GRE提供了相似的天然心肌T1测量值、精密度、重复性和主观图像质量。

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