1.5T 下单次屏气 2 维多层心肌 T 映射（FAST1）在三个屏气周期内实现全心室覆盖。

FASt single-breathhold 2D multislice myocardial T mapping (FAST1) at 1.5T for full left ventricular coverage in three breathholds.

机构信息

The School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

MR Research Collaborations, Siemens Healthcare Limited, Frimley, UK.

出版信息

J Magn Reson Imaging. 2020 Feb;51(2):492-504. doi: 10.1002/jmri.26869. Epub 2019 Jul 24.

DOI:10.1002/jmri.26869

PMID:31342614

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6954880/

Abstract

BACKGROUND

Conventional myocardial T mapping techniques such as modified Look-Locker inversion recovery (MOLLI) generate one T map per breathhold. T mapping with full left ventricular coverage may be desirable when spatial T variations are expected. This would require multiple breathholds, increasing patient discomfort and prolonging scan time.

PURPOSE

To develop and characterize a novel FASt single-breathhold 2D multislice myocardial T mapping (FAST1) technique for full left ventricular coverage.

STUDY TYPE

Prospective.

POPULATION/PHANTOM: Numerical simulation, agarose/NiCl phantom, 9 healthy volunteers, and 17 patients.

FIELD STRENGTH/SEQUENCE: 1.5T/FAST1.

ASSESSMENT

Two FAST1 approaches, FAST1-BS and FAST1-IR, were characterized and compared with standard 5-(3)-3 MOLLI in terms of accuracy, precision/spatial variability, and repeatability.

STATISTICAL TESTS

Kruskal-Wallis, Wilcoxon signed rank tests, intraclass correlation coefficient analysis, analysis of variance, Student's t-tests, Pearson correlation analysis, and Bland-Altman analysis.

RESULTS

In simulation/phantom, FAST1-BS, FAST1-IR, and MOLLI had an accuracy (expressed as T error) of 0.2%/4%, 6%/9%, and 4%/7%, respectively, while FAST1-BS and FAST1-IR had a precision penalty of 1.7/1.5 and 1.5/1.4 in comparison with MOLLI, respectively. In healthy volunteers, FAST1-BS/FAST1-IR/MOLLI led to different native myocardial T times (1016 ± 27 msec/952 ±22 msec/987 ± 23 msec, P < 0.0001) and spatial variability (66 ± 10 msec/57 ± 8 msec/46 ± 7 msec, P < 0.001). There were no statistically significant differences between all techniques for T repeatability (P = 0.18). In vivo native and postcontrast myocardial T times in both healthy volunteers and patients using FAST1-BS/FAST1-IR were highly correlated with MOLLI (Pearson correlation coefficient ≥0.93).

DATA CONCLUSION

FAST1 enables myocardial T mapping with full left ventricular coverage in three separated breathholds. In comparison with MOLLI, FAST1 yield a 5-fold increase of spatial coverage, limited penalty of T precision/spatial variability, no significant difference of T repeatability, and highly correlated T times. FAST1-IR provides improved T precision/spatial variability but reduced accuracy when compared with FAST1-BS.

LEVEL OF EVIDENCE

1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2020;51:492-504.

摘要

背景

传统的心肌 T 映射技术，如改良 Look-Locker 反转恢复（MOLLI），每次屏气可生成一个 T 映射。当预期存在空间 T 变化时，可能需要进行完整的左心室覆盖的 T 映射。这将需要多次屏气，增加患者的不适和延长扫描时间。

目的

开发并描述一种新的快速单次屏气二维多切片心肌 T 映射（FAST1）技术，用于完整的左心室覆盖。

研究类型

前瞻性。

人群/体模：数值模拟、琼脂/NiCl 体模、9 名健康志愿者和 17 名患者。

磁场强度/序列：1.5T/FAST1。

评估

对两种 FAST1 方法 FAST1-BS 和 FAST1-IR 进行了特征描述，并与标准 5-(3)-3 MOLLI 在准确性、精密度/空间变异性和可重复性方面进行了比较。

统计学检验

Kruskal-Wallis、Wilcoxon 符号秩检验、组内相关系数分析、方差分析、Student's t 检验、Pearson 相关分析和 Bland-Altman 分析。

结果

在模拟/体模中，FAST1-BS、FAST1-IR 和 MOLLI 的准确性（表示为 T 误差）分别为 0.2%/4%、6%/9%和 4%/7%，而 FAST1-BS 和 FAST1-IR 与 MOLLI 相比，精度分别下降了 1.7/1.5 和 1.5/1.4。在健康志愿者中，FAST1-BS/FAST1-IR/MOLLI 导致不同的固有心肌 T 时间（1016±27 毫秒/952±22 毫秒/987±23 毫秒，P<0.0001）和空间变异性（66±10 毫秒/57±8 毫秒/46±7 毫秒，P<0.001）。所有技术之间的 T 重复性没有统计学差异（P=0.18）。在健康志愿者和患者中，使用 FAST1-BS/FAST1-IR 的固有和对比后心肌 T 时间与 MOLLI 高度相关（Pearson 相关系数≥0.93）。

数据结论

FAST1 能够在三个单独的屏气中进行完整的左心室覆盖的心肌 T 映射。与 MOLLI 相比，FAST1 增加了 5 倍的空间覆盖范围，T 精度/空间变异性的限制很小，T 重复性没有显著差异，并且 T 时间高度相关。与 FAST1-BS 相比，FAST1-IR 提供了更好的 T 精度/空间变异性，但准确性降低。