急性甲基苯丙胺中毒期间血脑屏障和血脊髓屏障的破坏：脑温的作用
Breakdown of Blood-Brain and Blood-Spinal Cord Barriers During Acute Methamphetamine Intoxication: Role of Brain Temperature.
作者信息
Kiyatkin Eugene A, Sharma Hari S
机构信息
Behavioral Neuroscience Branch, NIDA-IRP, NIH, 333 Cassell Drive, Baltimore, MD 21224, USA.
出版信息
CNS Neurol Disord Drug Targets. 2016;15(9):1129-1138. doi: 10.2174/1871527315666160920112445.
Abstract
Methamphetamine (METH) is a powerful and often-abused stimulant with potent addictive and neurotoxic properties. While it is generally believed that structural brain damage induced by METH results from oxidative stress, in this work we present data suggesting robust disruption of blood-brain and blood-spinal cord barriers during acute METH intoxication in rats. We demonstrate the relationships between METH-induced brain hyperthermia and widespread but structure-specific barrier leakage, acute glial cell activation, changes in brain water and ionic homeostasis, and structural damage of different types of cells in the brain and spinal cord. Therefore, METH-induced leakage of the blood-brain and blood-spinal cord barriers is a significant contributor to different types of functional and structural brain abnormalities that determine acute toxicity of this drug and possibly neurotoxicity during its chronic use.
摘要
甲基苯丙胺（METH）是一种强效且常被滥用的兴奋剂，具有强大的成瘾性和神经毒性。虽然人们普遍认为METH诱导的脑结构损伤是由氧化应激引起的，但在这项研究中，我们提供的数据表明，大鼠急性METH中毒期间血脑屏障和血脊髓屏障受到了严重破坏。我们证明了METH诱导的脑部体温过高与广泛但具有结构特异性的屏障渗漏、急性胶质细胞活化、脑内水和离子稳态变化以及脑和脊髓中不同类型细胞的结构损伤之间的关系。因此，METH诱导的血脑屏障和血脊髓屏障渗漏是导致不同类型脑功能和结构异常的重要因素，这些异常决定了该药物的急性毒性，并可能在其长期使用过程中导致神经毒性。
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