氧气供应与代谢适应
Oxygen availability and metabolic adaptations.
作者信息
Nakazawa Michael S, Keith Brian, Simon M Celeste
机构信息
Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania.
Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania.
出版信息
Nat Rev Cancer. 2016 Sep 23;16(10):663-73. doi: 10.1038/nrc.2016.84.
Abstract
Oxygen availability, along with the abundance of nutrients (such as glucose, glutamine, lipids and albumin), fluctuates significantly during tumour evolution and the recruitment of blood vessels, leukocytes and reactive fibroblasts to complex tumour microenvironments. As such, hypoxia and concomitant nutrient scarcity affect large gene expression programmes, signalling pathways, diverse metabolic reactions and various stress responses. This Review summarizes our current understanding of how these adaptations are integrated in hypoxic tumour cells and their role in disease progression.
摘要
在肿瘤演变以及血管、白细胞和反应性成纤维细胞募集至复杂肿瘤微环境的过程中，氧的可利用性以及营养物质（如葡萄糖、谷氨酰胺、脂质和白蛋白）的丰度会发生显著波动。因此，缺氧和随之而来的营养物质匮乏会影响大量基因表达程序、信号通路、多种代谢反应及各种应激反应。本综述总结了我们目前对于这些适应性变化如何在缺氧肿瘤细胞中整合及其在疾病进展中的作用的理解。
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