Poplawsky A, Isaacson R L
Department of Psychology, Bloomsburg University of Pennsylvania 17815.
Brain Res. 1989 Aug 28;495(2):396-400. doi: 10.1016/0006-8993(89)90235-7.
The effects of a 5-day ganglioside (GM1) treatment (30 mg/kg) on body weight and water intake subsequent to medial septal lesions were evaluated for 44 consecutive days. In addition, activity, rearing, and repetitive motor acts were measured on postsurgery days 5, 10, 40, and 60. The rate of increase in the body weights of rats with medial septal lesions treated with GM1 was equivalent to that of controls, while untreated rats with such lesions had reduced body weights. Rats with medial septal lesions treated with GM1 also exhibited movement times and frequency of repetitious motor acts similar to those of control rats by postsurgery day 60. No differences were found in water intake between any of the groups. Rats with medial septal lesions, whether treated with GM1 or not, had equivalent frequencies of rearings that were lower than control rats. This study emphasizes that even brief regimes of GM1 administration can exert behavioral changes in brain-damaged rats well after the treatment was administered, i.e. 40-60 days after surgery.
评估了连续44天给予5天神经节苷脂（GM1，30毫克/千克）治疗对内侧隔区损伤后体重和水摄入量的影响。此外，在术后第5、10、40和60天测量了活动、竖毛和重复性运动行为。接受GM1治疗的内侧隔区损伤大鼠的体重增加率与对照组相当，而未接受治疗的此类损伤大鼠体重减轻。到术后第60天，接受GM1治疗的内侧隔区损伤大鼠的运动时间和重复性运动行为频率也与对照大鼠相似。各组之间的水摄入量没有差异。内侧隔区损伤的大鼠，无论是否接受GM1治疗，其竖毛频率相当，但低于对照大鼠。这项研究强调，即使是短暂的GM1给药方案，也能在给药后很长时间，即术后40 - 60天，对脑损伤大鼠产生行为改变。
