Isaacson R L, Poplawsky A
Department of Psychology, State University of New York at Binghamton 13902-6000.
Physiol Behav. 1993 Sep;54(3):569-73. doi: 10.1016/0031-9384(93)90251-a.
The effects of a 4-day nimodipine treatment (70 micrograms/kg IP beginning on the day of surgery) given to rats with lesions directed at the medial septal area were monitored for 120 days. Body weight, water intake, open-field activity, rearing, hole-poking, and repetitive motor acts were periodically measured through 120 postsurgical days. Although no differences were found in water intake between any of the groups, the body weights of rats with any medial septal damage, whether treated with nimodipine or not, were lower than rats with control operations by postsurgery day 120. Rats with any medial septal damage, whether treated with nimodipine or not, had lower rearing frequencies, rearing durations, and hole-poking frequencies than controls on all test days. However, rats with complete medial septal lesions treated with nimodipine exhibited movement in the open field and frequencies of stereotyped, species-typical acts similar to those of control rats by postsurgery day 60. This nimodipine effect was not observed in rats with partial lesions of the medial septal region. This study emphasizes that a brief administration of nimodipine shortly after brain damage can influence behavioral changes 40-60 days after surgery, but that this effect was not apparent in rats with only partial medial lesions.
对内侧隔区有损伤的大鼠给予4天尼莫地平治疗（从手术当天开始，腹腔注射70微克/千克），并监测120天。在术后120天内定期测量体重、饮水量、旷场活动、竖毛、戳洞和重复性运动行为。虽然各实验组之间的饮水量没有差异，但到术后第120天，任何内侧隔区有损伤的大鼠，无论是否接受尼莫地平治疗，其体重均低于接受对照手术的大鼠。在所有测试日，任何内侧隔区有损伤的大鼠，无论是否接受尼莫地平治疗，其竖毛频率、竖毛持续时间和戳洞频率均低于对照组。然而，到术后第60天，接受尼莫地平治疗的内侧隔区完全损伤的大鼠在旷场中的活动以及刻板的、物种典型行为的频率与对照大鼠相似。在内侧隔区部分损伤的大鼠中未观察到这种尼莫地平效应。本研究强调，脑损伤后不久短期给予尼莫地平可影响术后40 - 60天的行为变化，但这种效应在仅内侧隔区部分损伤的大鼠中并不明显。
