Sochorová R, Mosnárová A, Huzuláková I, Kyselovic J
Bratisl Lek Listy. 1989 Jun;90(6):436-40.
The reactivity of the isolated guinea pig uterus was studied after single (0.5 h before experiment) and repeated (7 days) in vivo testosterone administration in the dose of 10 mg.kg-1. In vitro testosterone was applied in the dose of 5.8 x 10(-5) mol. The reactivity of the isolated guinea pig uterus to norepinephrine, epinephrine, and acetylcholine was evaluated. These substances were applied cumulatively in doses of 10(-8) - 10(-4) mol.I-1. The changes of isometric contractions of the uterus were evaluated by the magnitude of the maximal response and by the pD2 value. The contractile response of the guinea pig uterus to all the mediators studied was decreased both after in vitro and in vivo administration of testosterone. The most pronounced change in the pD2 value was induced by single testosterone administration. The results suggest that, similarly as female sex hormones, testosterone may influence uterine function by its effect at receptor and nonreceptor level.
在以10mg.kg-1的剂量单次（实验前0.5小时）和重复（7天）体内给予睾酮后，研究了分离的豚鼠子宫的反应性。体外给予睾酮的剂量为5.8×10(-5)mol。评估了分离的豚鼠子宫对去甲肾上腺素、肾上腺素和乙酰胆碱的反应性。这些物质以10(-8)-10(-4)mol.I-1的剂量累积给药。通过最大反应幅度和pD2值评估子宫等长收缩的变化。在体外和体内给予睾酮后，豚鼠子宫对所有研究介质的收缩反应均降低。单次给予睾酮引起pD2值最明显的变化。结果表明，与雌性激素一样，睾酮可能通过其在受体和非受体水平的作用影响子宫功能。
