Sakoda H
Nihon Sanka Fujinka Gakkai Zasshi. 1980 Jun;32(6):697-705.
Effects of estrogen (abbr. as E), Estrogen + Progesterone (E + P) and autonomic nerve trophic drugs on uterus were investigated in rabbit and human in vivo and the following results were obtained. 1) Spontaneous contraction in cornu and cervix of E treated rabbit were stronger than in those during pregnancy or treated with E + P. 2) 10(-5) g/kg Adrenaline caused a uniform response pattern in cornu and cervix of E treated rabbit, and the pattern could be divided into three phases. Phase I is supposed to be the contraction response through the alpha receptor, and phase II is presumed as the response that comprises a part of element identical with alpha adrenergic response, while phase III is the relaxation response through the beta 2 receptor. 3) Acetylcholine (ACh) 10(-3) g/kg and Neostigmine 10(-5) g/kg caused augmentation of contraction both in cornu and cervix of rabbit, but this effect was blocked by Atropine, suggesting the presence of parasympathetic control in cornu and cervix. 4) In human corpus and cervix, Phenylephrine and ACh augmented contraction but Terbutaline had reducing contraction, showing the similar phenomenon found in rabbit. From this, it was proven that the similar autonomic nerve controls could be present both in rabbit and human.
在兔和人体中研究了雌激素（简称E）、雌激素+孕激素（E+P）及自主神经滋养药物对子宫的影响，结果如下：1）雌激素处理的兔子宫角和宫颈的自发收缩比妊娠时或雌激素+孕激素处理时更强。2）10（-5）g/kg肾上腺素在雌激素处理的兔子宫角和宫颈引起一致的反应模式，该模式可分为三个阶段。第一阶段被认为是通过α受体的收缩反应，第二阶段被推测为包含与α肾上腺素能反应部分相同成分的反应，而第三阶段是通过β2受体的舒张反应。3）10（-3）g/kg乙酰胆碱（ACh）和10（-5）g/kg新斯的明使兔子宫角和宫颈的收缩增强，但这种作用被阿托品阻断，提示子宫角和宫颈存在副交感神经控制。4）在人体子宫体和宫颈，去氧肾上腺素和乙酰胆碱增强收缩，但特布他林减弱收缩，这与兔中发现的现象相似。由此证明，兔和人可能存在相似的自主神经控制。
