Dupré A, Mousseaux C, Bouguerba A, Ayed S, Barchazs J, Boukari M, Goldgran-Toledano D, Bornstain C, Vincent F
Réanimation polyvalente, Groupe Hospitalier intercommunal Le Raincy-Montfermeil, 10, avenue du Général-Leclerc, 93370 Montfermeil, France.
Réanimation polyvalente, Groupe Hospitalier intercommunal Le Raincy-Montfermeil, 10, avenue du Général-Leclerc, 93370 Montfermeil, France.
Rev Med Interne. 2017 Jan;38(1):36-43. doi: 10.1016/j.revmed.2016.08.021. Epub 2016 Sep 19.
Whether it appears spontaneously or is induced by therapy, the tumor lysis syndrome is responsible for a massive release of ions and puric bases degradation of products in the circulation exceeding the renal excretion capacity. Some, such as uric acid, xanthine, and calcium phosphate, can precipitate in the renal tubules or parenchyma. It must be known to any practitioner supporting patients with hematologic malignancies, mainly high-grade but also some solid tumors. The 2015 publication of the British recommendations pertaining to patients suffering from hematological diseases should be broadcast. The main goal of treatment is to prevent the occurrence of renal dysfunction associated with heavy morbidity and mortality, either for his own conduct or consequences on obtaining a good tumor response. Some items proposed for the care, whether curative or preventive, should be discussed or detailed, which is the subject of this paper.
无论肿瘤溶解综合征是自发出现还是由治疗诱发,它都会导致循环中离子大量释放以及嘌呤碱基降解产物的释放,超过肾脏排泄能力。其中一些物质,如尿酸、黄嘌呤和磷酸钙,可在肾小管或实质中沉淀。任何为血液系统恶性肿瘤患者提供支持的从业者都必须了解这一点,主要是高级别血液系统恶性肿瘤患者,但也包括一些实体瘤患者。2015年英国发布的有关血液病患者的建议应予以传播。治疗的主要目标是预防与高发病率和死亡率相关的肾功能障碍的发生,无论是其自身的影响还是对获得良好肿瘤反应的后果。本文将讨论或详述一些针对治疗(无论是治愈性还是预防性)所提出的项目。