Schweyer Kerstin, Mantel Tobias, Knier Benjamin, Aly Lilian, Kirschke Jan S, Meindl Tobias, Haslinger Bernhard
Department of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
TUM Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Brain Behav. 2025 May;15(5):e70509. doi: 10.1002/brb3.70509.
Research links retinal changes to cognitive decline in Parkinson's disease (PD), paralleling findings in Alzheimer's, raising questions about specific cortical patterns of cognition-related retinal abnormalities in PD.
The study aimed to explore whether retinal thinning linked to cognitive decline could act as a potential biomarker for cerebral atrophy in PD.
Twenty seven patients with PD underwent cognitive and neurological assessments, along with retinal imaging using OCT and cerebral imaging using structural MRI. After identifying abnormal retinal layers associated with cognitive dysfunction through partial correlation analyses controlling for age-related effects, associations between these retinal layers and the parcellated cerebral gray matter were assessed using multiple comparison-corrected partial correlation analyses adjusted for age and gender.
Significant positive correlations were found between cognitive impairment measured by MoCA and specific retinal layers (IPL, GCL, and RNFL). Of these, strong associations were observed between the IPL and GCL and cortical thickness in brain the temporal lobe and limbic cortex, with more detailed further analysis showing significant correlations particularly within the middle and posterior cingulate cortex in the limbic cortex and the middle and superior temporal gyrus in the temporal lobe.
Correlations between retinal thinning, cognitive decline, and specific patterns of cortical atrophy in PD support a potential of retinal measurements as a biomarker for cognitive impairment linked to cerebral neurodegeneration.
研究将视网膜变化与帕金森病（PD）的认知衰退联系起来，这与阿尔茨海默病的研究结果相似，引发了关于PD中与认知相关的视网膜异常的特定皮质模式的问题。
本研究旨在探讨与认知衰退相关的视网膜变薄是否可作为PD脑萎缩的潜在生物标志物。
27例PD患者接受了认知和神经学评估，以及使用光学相干断层扫描（OCT）的视网膜成像和使用结构磁共振成像（MRI）的脑成像。通过控制年龄相关效应的偏相关分析确定与认知功能障碍相关的异常视网膜层后，使用针对年龄和性别进行调整的多重比较校正偏相关分析评估这些视网膜层与脑灰质分区之间的关联。
蒙特利尔认知评估量表（MoCA）测量的认知障碍与特定视网膜层（内层视网膜神经纤维层、神经节细胞层和视网膜神经纤维层）之间存在显著正相关。其中，在内层视网膜神经纤维层和神经节细胞层与颞叶和边缘皮质的皮质厚度之间观察到强关联，进一步详细分析显示，特别是在边缘皮质的中扣带回和后扣带回以及颞叶的颞中回和颞上回内存在显著相关性。
PD中视网膜变薄、认知衰退和特定皮质萎缩模式之间的相关性支持视网膜测量作为与脑神经元变性相关的认知障碍生物标志物的潜力。
