Shimamura Norihito, Mtsuda Naoya, Ktayama Kosuke, Kakuta Kiyohide, Katagai Takeshi, Naraoka Masato, Ohkuma Hiroki
Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 5-Zaihuchou, Hirosaki Aomori Pref. 036-8562, Japan.
Curr Drug Deliv. 2017 Sep 6;14(6):758-765. doi: 10.2174/1567201813666160922115830.
An insult due to intracerebral hemorrhage (ICH) is critical to patients. So, breakthroughs in ICH treatment are very important.
Advances in the stem cell treatment of stroke have been remarkable. And stem cell experimentation on ischemic stroke, however, preceded such work on ICH and did not emphasized ICH therapy.
We review recent stem cell treatments for ICH, an experimental model of ICH, the medical care of ICH, and several stem cell therapies for ICH along with future prospects.
Stem cell therapy for ICH is effective in rodent or animal models. For humans, only a small number of clinical trials have been done, and significant functional recovery was recorded.
We need to reveal the mechanism of stem cell therapy and develop a reliable, definitive treatment strategy for treatment of ICH. In the future, several types of stem cells will be available for the treatment of ICH.
脑出血（ICH）所致损伤对患者至关重要。因此，脑出血治疗方面的突破非常重要。
中风的干细胞治疗进展显著。然而，缺血性中风的干细胞实验先于脑出血相关工作，且未强调脑出血治疗。
我们综述了近期脑出血的干细胞治疗、脑出血实验模型、脑出血的医疗护理以及几种脑出血的干细胞疗法及其未来前景。
脑出血的干细胞疗法在啮齿动物或动物模型中有效。对于人类，仅进行了少数临床试验，且记录到显著的功能恢复。
我们需要揭示干细胞治疗的机制，并开发一种可靠、明确的脑出血治疗策略。未来，几种类型的干细胞将可用于治疗脑出血。
