Ma Xun, Qin Jie, Song Bo, Shi Changhe, Zhang Rui, Liu Xinjing, Ji Yan, Ji Wei, Gong Guangming, Xu Yuming
Third Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, People's Republic of China,
Neurol Sci. 2015 Aug;36(8):1311-7. doi: 10.1007/s10072-015-2238-6. Epub 2015 May 14.
Stem cell to be a new intervention for treating intracerebral hemorrhage (ICH) might benefit humans. Therefore, we collected animal studies to find the effect of this innovative treatment. In July 2014, we searched Medline (from 1950), Embase (from 1980), China Biology Medicine disk (from 1978) for studies on stem cells used for treating experimental ICH in animal models that reported neurobehavioral and structural outcome. We evaluated the quality of these studies and used a weighted mean difference random affects model for the meta-analysis. We have collected 30 studies from 650 publications identified through systematic review describing the effects of 5 different type of stem cells on 12 different neurobehavioral scales with 1101 rodents or monkeys. Although there is lack of uniformity of the evaluation methods, these researches showed consistent improvements both in neurobehavioral function and structural outcomes. Besides, the quality of these studies needs to be raised. In conclusion, stem cells hold extensive potential in treating ICH, which should be further evaluated with more evidence-based, high-quality animal studies.
干细胞作为一种治疗脑出血（ICH）的新干预手段可能会造福人类。因此，我们收集了动物研究来探寻这种创新治疗方法的效果。2014年7月，我们检索了Medline（自1950年起）、Embase（自1980年起）、中国生物医学光盘数据库（自1978年起），以查找关于在动物模型中使用干细胞治疗实验性ICH并报告神经行为和结构结果的研究。我们评估了这些研究的质量，并使用加权平均差随机效应模型进行荟萃分析。我们从通过系统评价确定的650篇出版物中收集了30项研究，这些研究描述了5种不同类型的干细胞对1101只啮齿动物或猴子的12种不同神经行为量表的影响。尽管评估方法缺乏一致性，但这些研究表明神经行为功能和结构结果均有一致改善。此外，这些研究的质量有待提高。总之，干细胞在治疗ICH方面具有广阔潜力，应通过更多基于证据的高质量动物研究进行进一步评估。
