Katuwavila Nuwanthi P, Perera A D L C, Dahanayake Damayanthi, Karunaratne V, Amaratunga Gehan A J, Karunaratne D Nedra
Post Graduate Institute of Science, University of Peradeniya, Peradeniya, Sri Lanka; SriLanka Institute of Nanotechnology, Mahenwatta, Pitipana, Homagama, Sri Lanka.
Post Graduate Institute of Science, University of Peradeniya, Peradeniya, Sri Lanka; Dept. of Chemistry, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka.
Int J Pharm. 2016 Nov 20;513(1-2):404-409. doi: 10.1016/j.ijpharm.2016.09.053. Epub 2016 Sep 19.
A novel, efficient delivery system for iron (Fe) was developed using the alginate biopolymer. Iron loaded alginate nanoparticles were synthesized by a controlled ionic gelation method and was characterized with respect to particle size, zeta potential, morphology and encapsulation efficiency. Successful loading was confirmed with Fourier Transform Infrared spectroscopy and Thermogravimetric Analysis. Electron energy loss spectroscopy study corroborated the loading of ferrous into the alginate nanoparticles. Iron encapsulation (70%) was optimized at 0.06% Fe (w/v) leading to the formation of iron loaded alginate nanoparticles with a size range of 15-30nm and with a negative zeta potential (-38mV). The in vitro release studies showed a prolonged release profile for 96h. Release of iron was around 65-70% at pH of 6 and 7.4 whereas it was less than 20% at pH 2.The initial burst release upto 8h followed zero order kinetics at all three pH values. All the release profiles beyond 8h best fitted the Korsmeyer-Peppas model of diffusion. Non Fickian diffusion was observed at pH 6 and 7.4 while at pH 2 Fickian diffusion was observed.
利用海藻酸盐生物聚合物开发了一种新型高效的铁（Fe）递送系统。通过可控离子凝胶法合成了负载铁的海藻酸盐纳米颗粒，并对其粒径、zeta电位、形态和包封率进行了表征。通过傅里叶变换红外光谱和热重分析证实了成功负载。电子能量损失光谱研究证实了亚铁负载到海藻酸盐纳米颗粒中。在0.06%Fe（w/v）时优化了铁包封率（70%），从而形成了粒径范围为15-30nm且zeta电位为负（-38mV）的负载铁的海藻酸盐纳米颗粒。体外释放研究表明其具有长达96小时的缓释曲线。在pH值为6和7.4时，铁的释放率约为65-70%，而在pH值为2时，释放率小于20%。在所有三个pH值下，长达8小时的初始突释遵循零级动力学。8小时后的所有释放曲线最符合Korsmeyer-Peppas扩散模型。在pH值为6和7.4时观察到非Fickian扩散，而在pH值为2时观察到Fickian扩散。
Zotero 插件