Arshad Rizwan, Gulshad Lubaba, Haq Iahtisham-Ul-, Farooq Muhammad Adil, Al-Farga Ammar, Siddique Rabia, Manzoor Muhammad Faisal, Karrar Emad
University Institute of Diet and Nutritional Sciences The University of Lahore, Gujrat Campus Gujrat Pakistan.
School of Food and Nutrition Faculty of Allied Health Sciences Minhaj University Lahore Pakistan.
Food Sci Nutr. 2021 May 4;9(6):3354-3361. doi: 10.1002/fsn3.2311. eCollection 2021 Jun.
Nanotechnology has revolutionized the field of food systems, diagnostics, therapeutics, pharmaceuticals, the agriculture sector, and nutraceuticals. Nanoparticles are playing important role in giving the solution to enhance bioavailability of oral delivery of bioactive compounds. This review revealed that nanoparticles can improve the bioavailability of micronutrients, for example, vitamin B, vitamin A, folic acid, and iron. However, toxicity associated with nanoparticle-based delivery systems is still a major concern after ingestion of nano-based supplements. The mode of the mechanism of nanomaterial along with bioactive components in different physiological conditions of the human body is also a major gap in the field of nanoceuticals. In the future, more evidence-based clinical investigations are needed to confirm the exact approach to physiological changes in the human body.
纳米技术已经彻底改变了食品系统、诊断、治疗、制药、农业和营养保健品等领域。纳米颗粒在解决提高生物活性化合物口服给药的生物利用度方面发挥着重要作用。这篇综述表明，纳米颗粒可以提高微量营养素的生物利用度，例如维生素B、维生素A、叶酸和铁。然而，摄入纳米基补充剂后，基于纳米颗粒的递送系统的毒性仍然是一个主要问题。在人体不同生理条件下，纳米材料与生物活性成分的作用机制模式也是纳米药物领域的一个主要空白。未来，需要更多基于证据的临床研究来确认人体生理变化的确切方法。
