来自多叶岩黄芪的两种新的异戊烯基化异黄酮。

Two new prenylated isoflavones from Hedysarum multijugum.

作者信息

Wang Wei, Zhao Yu-Ying, Chen Hubiao, Zhang Qing-Ying, Liang Hong

机构信息

a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences , Peking University , Beijing 100191 , China.

b State Key Laboratory of Membrane Biology, School of Life Sciences , Tsinghua University , Beijing 100084 , China.

出版信息

J Asian Nat Prod Res. 2017 May;19(5):444-447. doi: 10.1080/10286020.2016.1231672. Epub 2016 Sep 23.

DOI:10.1080/10286020.2016.1231672

PMID:27660003

Abstract

Chemical investigation on the ethyl acetate extract of the roots of Hedysarum multijugum resulted in the isolation of two new prenylated isoflavonoids: 5, 7, 2'-trihydroxy-4'-methoxy-3'-(γ, γ-dimethylallyl) isoflavone (hedysarimisoflavone A, 1) and 5, 7, 2'-trihydroxy-4'-methoxy-6, 8-di-(γ, γ-dimethylallyl) isoflavone (hedysarimisoflavone B, 2). Their structures were elucidated on the basis of spectroscopic analyses, especially, H and C NMR spectra in conjunction with their 2D experiments, H-H COSY, HMQC, HMBC, and NOESY.

摘要

对多序岩黄芪根的乙酸乙酯提取物进行化学研究，从中分离出两种新的异戊烯基化异黄酮：5,7,2'-三羟基-4'-甲氧基-3'-(γ,γ-二甲基烯丙基)异黄酮（岩黄耆异黄酮A，1）和5,7,2'-三羟基-4'-甲氧基-6,8-二-(γ,γ-二甲基烯丙基)异黄酮（岩黄耆异黄酮B，2）。通过光谱分析，特别是结合二维实验（H-H COSY、HMQC、HMBC和NOESY）的氢谱和碳谱，阐明了它们的结构。