来自菲律宾千斤拔的异戊烯基化异黄酮。

Prenylated isoflavones from Flemingia philippinensis.

作者信息

Li Hua, Yang Meihua, Miao Jianhua, Ma Xiaojun

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China.

出版信息

Magn Reson Chem. 2008 Dec;46(12):1203-7. doi: 10.1002/mrc.2336.

DOI:10.1002/mrc.2336

PMID:18821576

Abstract

Two new prenylated isoflavones, named flemiphilippinins E and F, were isolated from the roots of Flemingia philippinensis, together with six known ones. The structures of the above compounds were established by spectroscopic methods. Flemiphilippinins E and F were identified as 5,4'-dihydroxy-8-(3,3-dimethylallyl)-6'',6''-dimethyl-5''-(1,1-dimethylallyl) pyrano(2'',3'':7,6)isoflavone and 5,4'-dihydroxy-4'',4'',5''-trimethyl-4'',5''-dihydrofurano(2'',3'':7,8) isoflavone, respectively, by a combination of HR-EI-MS, (1)H NMR, (13)C NMR, HMQC, HMBC, and NOESY spectra.

摘要

从菲律宾千斤拔的根部分离出两种新的异戊烯基化异黄酮，命名为菲律宾千斤拔素E和F，以及六种已知的异黄酮。上述化合物的结构通过光谱方法确定。通过高分辨电子轰击质谱（HR-EI-MS）、氢核磁共振谱（¹H NMR）、碳核磁共振谱（¹³C NMR）、异核多量子相干谱（HMQC）、异核多键相关谱（HMBC）和核Overhauser效应谱（NOESY）等多种谱图的综合分析，分别鉴定菲律宾千斤拔素E为5,4'-二羟基-8-(3,3-二甲基烯丙基)-6'',6''-二甲基-5''-(1,1-二甲基烯丙基)吡喃并(2'',3'':7,6)异黄酮，菲律宾千斤拔素F为5,4'-二羟基-4'',4'',5''-三甲基-4'',5''-二氢呋喃并(2'',3'':7,8)异黄酮。