Perks A M, Cassin S
Department of Zoology, University of British Columbia, Vancouver, Canada.
Can J Physiol Pharmacol. 1989 May;67(5):491-8. doi: 10.1139/y89-078.
The effects of arginine vasopressin (AVP) and epinephrine on lung liquid secretion were investigated in 67 acute fetal goats (116 days of gestation to term) with intact umbilical cords after caesarean section. Secretion was measured by an impermeant tracer technique. AVP was infused intravenously (1.6-39.2 mU/(kg.min); 2 h) into 26 fetuses. All fetuses below 130 days of gestation, except one, showed no response. All above 133 days reduced secretion, or turned to reabsorption, except at the lowest infusion rate. The effect persisted, and usually increased postinfusion. Expansion of the lungs with saline did not change the response. The percentage reductions were linearly related to the logarithm of the infusion rate (threshold, 1.42 mU/(kg.min]. The absolute reductions were linearly related to fetal weight. Epinephrine was infused intravenously (0.30-6.72 micrograms/(kg.min); 1-2 h) into 12 fetuses. All fetuses (118 days to term) reduced secretion or reabsorbed by the second hour. At the highest infusion rate, reabsorption was immediate; at the lowest, secretion increased slightly, then fell significantly in the second hour. Epinephrine acted at levels considered physiological at delivery in the sheep. AVP appears to act at plasma levels found in most vaginal deliveries; it may augment epinephrine-induced reabsorption during stress, and help long-term removal of lung fluid.
在67只剖宫产术后脐带完整的急性胎羊（妊娠116天至足月）中，研究了精氨酸加压素（AVP）和肾上腺素对肺液分泌的影响。通过一种非渗透性示踪技术测量分泌情况。将AVP静脉输注（1.6 - 39.2 mU/(kg·min)；持续2小时）给26只胎儿。所有妊娠130天以下的胎儿，除一只外，均无反应。所有妊娠133天以上的胎儿，除最低输注速率外，均出现分泌减少或转为重吸收。这种效应持续存在，且通常在输注后增强。用盐水扩张肺脏并未改变反应。减少的百分比与输注速率的对数呈线性相关（阈值为1.42 mU/(kg·min)）。绝对减少量与胎儿体重呈线性相关。将肾上腺素静脉输注（0.30 - 6.72微克/(kg·min)；持续1 - 2小时）给12只胎儿。所有胎儿（妊娠118天至足月）在第二小时时分泌减少或开始重吸收。在最高输注速率时，重吸收立即发生；在最低输注速率时，分泌略有增加，然后在第二小时显著下降。肾上腺素在羊分娩时被认为是生理水平下起作用。AVP似乎在大多数阴道分娩时的血浆水平下起作用；它可能在应激期间增强肾上腺素诱导的重吸收，并有助于肺液的长期清除。
