Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation.
作者信息
Greil Johann, Verga-Falzacappa Maria V, Echner Nicole E, Behnisch Wolfgang, Bandapalli Obul R, Pechanska Paulina, Immenschuh Stephan, Vijayan Vijith, Balla Jozsef, Tsukahara Hirokatsu, Schneider Marion, Janka Gritta, Claus Maren, Longerich Thomas, Muckenthaler Martina U, Kulozik Andreas E
机构信息
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany.
Institute for Transfusion Medicine, Hannover Medical School, Germany.
出版信息
Haematologica. 2016 Nov;101(11):e436-e439. doi: 10.3324/haematol.2016.147090. Epub 2016 Aug 4.
Abstract
摘要
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Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation.将血红素加氧酶-1突变为过氧化物酶会导致与小细胞性贫血和严重炎症相关的胆红素合成缺陷。
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Blood. 2016 Jan 28;127(4):473-86. doi: 10.1182/blood-2015-08-663245. Epub 2015 Dec 16.
2
Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia.人类血红素加氧酶-1缺乏症表现为溶血、肾炎和无脾。
J Pediatr Hematol Oncol. 2011 Jan;33(1):74-8. doi: 10.1097/MPH.0b013e3181fd2aae.
3
Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution.血红素氧合酶 1 缺陷小鼠血红素回收系统功能障碍：对巨噬细胞活力和组织铁分布的影响。
Blood. 2010 Dec 23;116(26):6054-62. doi: 10.1182/blood-2010-03-272138. Epub 2010 Sep 15.
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Mechanisms of cell protection by heme oxygenase-1.血红素加氧酶-1 的细胞保护机制。
Annu Rev Pharmacol Toxicol. 2010;50:323-54. doi: 10.1146/annurev.pharmtox.010909.105600.
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The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1.血红素加氧酶-1/一氧化碳途径通过调节Toll样受体4（TLR4）与小窝蛋白-1的相互作用来抑制TLR4信号传导。
J Immunol. 2009 Mar 15;182(6):3809-18. doi: 10.4049/jimmunol.0712437.
6
HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.HLH-2004：噬血细胞性淋巴组织细胞增生症的诊断与治疗指南。
Pediatr Blood Cancer. 2007 Feb;48(2):124-31. doi: 10.1002/pbc.21039.
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J Biol Inorg Chem. 2005 Mar;10(2):138-46. doi: 10.1007/s00775-004-0620-6. Epub 2005 Feb 3.
8
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Modern management of children with haemophagocytic lymphohistiocytosis.噬血细胞性淋巴组织细胞增生症患儿的现代管理
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