Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation.
作者信息
Greil Johann, Verga-Falzacappa Maria V, Echner Nicole E, Behnisch Wolfgang, Bandapalli Obul R, Pechanska Paulina, Immenschuh Stephan, Vijayan Vijith, Balla Jozsef, Tsukahara Hirokatsu, Schneider Marion, Janka Gritta, Claus Maren, Longerich Thomas, Muckenthaler Martina U, Kulozik Andreas E
机构信息
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany.
Institute for Transfusion Medicine, Hannover Medical School, Germany.
出版信息
Haematologica. 2016 Nov;101(11):e436-e439. doi: 10.3324/haematol.2016.147090. Epub 2016 Aug 4.
Abstract
摘要
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本文引用的文献
1
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Blood. 2016 Jan 28;127(4):473-86. doi: 10.1182/blood-2015-08-663245. Epub 2015 Dec 16.
2
Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia.
J Pediatr Hematol Oncol. 2011 Jan;33(1):74-8. doi: 10.1097/MPH.0b013e3181fd2aae.
3
Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution.
Blood. 2010 Dec 23;116(26):6054-62. doi: 10.1182/blood-2010-03-272138. Epub 2010 Sep 15.
4
Mechanisms of cell protection by heme oxygenase-1.
Annu Rev Pharmacol Toxicol. 2010;50:323-54. doi: 10.1146/annurev.pharmtox.010909.105600.
5
The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1.
J Immunol. 2009 Mar 15;182(6):3809-18. doi: 10.4049/jimmunol.0712437.
6
HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.
Pediatr Blood Cancer. 2007 Feb;48(2):124-31. doi: 10.1002/pbc.21039.
7
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J Biol Inorg Chem. 2005 Mar;10(2):138-46. doi: 10.1007/s00775-004-0620-6. Epub 2005 Feb 3.
8
Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis.
Immunol Rev. 2005 Feb;203:165-79. doi: 10.1111/j.0105-2896.2005.00224.x.
9
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10
Heme oxygenase-1 deficiency: the first autopsy case.
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