胱抑素C水平升高与帕金森病的认知障碍及病情进展相关。

Elevated Cystatin C Levels Are Associated with Cognitive Impairment and Progression of Parkinson Disease.

作者信息

Hu Wei-Dong, Chen Jing, Mao Cheng-Jie, Feng Ping, Yang Ya-Ping, Luo Wei-Feng, Liu Chun-Feng

机构信息

*Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, and ‡Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China †Institute of Neuroscience, Soochow University, Suzhou, China.

出版信息

Cogn Behav Neurol. 2016 Sep;29(3):144-9. doi: 10.1097/WNN.0000000000000100.

DOI:10.1097/WNN.0000000000000100

PMID:27662452

Abstract

OBJECTIVE

We investigated the relationship between serum cystatin C (CysC) levels and cognitive dysfunction and disease progression in patients with Parkinson disease.

BACKGROUND

Previous studies have reported altered CysC levels in neurodegenerative disorders, but only a few studies have explored the role of CysC and its relationship to cognitive dysfunction in Parkinson disease.

METHODS

We measured serum levels of CysC, creatinine, urea, and uric acid in 142 patients with Parkinson disease and 146 healthy controls. We assessed disease progression using the Hoehn and Yahr scale, and cognitive function using the Montreal Cognitive Assessment (Beijing version).

RESULTS

The patients with Parkinson disease had significantly higher CysC levels than the controls (P<0.001). CysC level correlated significantly with age (r=0.494, P<0.001), sex (r=0.150, P=0.011), and serum creatinine level (r=0.377, P<0.001), but not with levels of urea or uric acid (P>0.05). CysC level was a significant independent predictor of Parkinson disease (odds ratio=23.143, 95% confidence interval: 5.485-97.648, P<0.001) in multivariate logistic regression analysis. In the Parkinson disease group, a higher CysC level was associated with a more advanced Hoehn and Yahr stage (r=0.098, P<0.05) and a lower Montreal Cognitive Assessment score (r=-0.381, P=0.003).

CONCLUSIONS

Serum CysC levels can predict disease severity and cognitive dysfunction in patients with Parkinson disease. The exact role of CysC remains to be determined.

摘要

目的

我们研究了帕金森病患者血清胱抑素C（CysC）水平与认知功能障碍及疾病进展之间的关系。

背景

既往研究报道了神经退行性疾病中CysC水平的改变，但仅有少数研究探讨了CysC在帕金森病中的作用及其与认知功能障碍的关系。

方法

我们测定了142例帕金森病患者和146名健康对照者的血清CysC、肌酐、尿素和尿酸水平。我们使用Hoehn和Yahr量表评估疾病进展，使用蒙特利尔认知评估量表（北京版）评估认知功能。

结果

帕金森病患者的CysC水平显著高于对照组（P<0.001）。CysC水平与年龄显著相关（r=0.494，P<0.001）、性别（r=0.150，P=0.011）和血清肌酐水平（r=0.377，P<0.001），但与尿素或尿酸水平无关（P>0.05）。在多因素逻辑回归分析中，CysC水平是帕金森病的显著独立预测因子（比值比=23.143，95%置信区间：5.485-97.648，P<0.001）。在帕金森病组中，较高的CysC水平与更高级别的Hoehn和Yahr分期相关（r=0.098，P<0.05），与较低的蒙特利尔认知评估得分相关（r=-（此处原文有误，应是-0.381），P=0.003）。