Barrios L, Miró R, Caballín M R, Fuster C, Guedea F, Subias A, Egozcue J
Departament de Biologia Cellular i Fisiologia, Universitat Autònoma de Barcelona, Spain.
Cancer Genet Cytogenet. 1989 Aug;41(1):61-70. doi: 10.1016/0165-4608(89)90108-8.
A total of 660 breakpoints were identified in the chromosome aberrations detected in lymphocytes from cancer patients after radiotherapy. The results show that chromosomes 1, 3, and 7 were significantly more affected than other chromosomes by ionizing radiation in vivo. Chromosome arms 1p, 1q, 7q, and 11p were also significantly more affected. Some bands also showed a special sensitivity to radiation, and band 1q32 was the most affected. This band is proposed as a "hot point" for the clastogenic effect of ionizing radiation. A significant clustering of breakpoints in G bands was also found, especially at the telomeres, as previously described by other authors. Clustering of breakpoints was also observed in bands where fragile sites, protooncogenes, breakpoints involved in chromosomal cancer rearrangements, and breakpoints involved in chromosomal evolution of the Hominoidea are located.
在放疗后的癌症患者淋巴细胞中检测到的染色体畸变中共鉴定出660个断点。结果表明，在体内，1号、3号和7号染色体受电离辐射的影响明显大于其他染色体。1号染色体短臂（1p）、长臂（1q）、7号染色体长臂（7q）和11号染色体短臂（11p）也受到了明显更大的影响。一些带对辐射也表现出特殊的敏感性，其中1q32带受影响最大。该带被认为是电离辐射致断裂效应的一个“热点”。正如其他作者先前所述，在G带中也发现了断点的显著聚集，尤其是在端粒处。在脆性位点、原癌基因、参与染色体癌重排的断点以及参与类人猿染色体进化的断点所在的带中也观察到了断点的聚集。
