Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Int J Mol Sci. 2022 Mar 29;23(7):3748. doi: 10.3390/ijms23073748.
Common pancreatic diseases have caused significant economic and social burdens worldwide. The interstitial microenvironment is involved in and plays a crucial part in the occurrence and progression of pancreatic diseases. Innate lymphoid cells (ILCs), an innate population of immune cells which have only gradually entered our visual field in the last 10 years, play an important role in maintaining tissue homeostasis, regulating metabolism, and participating in regeneration and repair. Recent evidence indicates that ILCs in the pancreas, as well as in other tissues, are also key players in pancreatic disease and health. Herein, we examined the possible functions of different ILC subsets in common pancreatic diseases, including diabetes mellitus, pancreatitis and pancreatic cancer, and discussed the potential practical implications of the relevant findings for future further treatment of these pancreatic diseases.
常见的胰腺疾病在全球范围内造成了巨大的经济和社会负担。间质微环境参与并在胰腺疾病的发生和进展中起着关键作用。先天淋巴细胞（ILC）是一种先天免疫细胞群体，在过去的 10 年中才逐渐进入我们的视野，它们在维持组织稳态、调节代谢以及参与再生和修复方面发挥着重要作用。最近的证据表明，胰腺以及其他组织中的 ILC 也是常见胰腺疾病和健康的关键参与者。在此，我们研究了不同 ILC 亚群在包括糖尿病、胰腺炎和胰腺癌在内的常见胰腺疾病中的可能功能，并讨论了相关发现对未来进一步治疗这些胰腺疾病的潜在实际意义。
