生药杀螺活性的筛选。

Screening for molluscicidal activity in crude drugs.

作者信息

Takeda O, Tanaka S, Yamasaki K, Kohda H, Iwanaga Y, Tsuji M

出版信息

Chem Pharm Bull (Tokyo). 1989 Apr;37(4):1090-1. doi: 10.1248/cpb.37.1090.

DOI:10.1248/cpb.37.1090

Abstract

Thirty-four extracts of crude drugs and medicinal plants have been screened for activity against Oncomelania nosophora, the intermediate host of the Japanese strain of Schistosoma japonicum. Strong molluscicidal activity was found in the MeOH extract of Anemarrhenae Rhizoma. Although timosaponin A-III, one of the main saponins of Anemarrhenae Rhizoma, showed very strong killing activity, markogenin-3-O-beta-D-glucopyranosyl (1-2)-O-beta-D-galactopyranoside having the same glycosidic linkage was found to be inactive.

摘要

对34种生药和药用植物提取物进行了抗日本血吸虫日本株中间宿主钉螺的活性筛选。知母甲醇提取物具有很强的杀螺活性。虽然知母的主要皂苷之一知母皂苷A-III表现出很强的杀灭活性，但具有相同糖苷键的马尔可皂苷元-3-O-β-D-吡喃葡萄糖基（1-2）-O-β-D-吡喃半乳糖苷却无活性。