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A new pharmacological testing method--different effects of levamisole and the serum of mice orally treated with levamisole on mitogenic activity of lipopolysaccharide.

作者信息

Amagaya S, Harada K, Miyake A, Iwama H, Ogihara Y

出版信息

Chem Pharm Bull (Tokyo). 1989 Apr;37(4):1117-9. doi: 10.1248/cpb.37.1117.

DOI:10.1248/cpb.37.1117
PMID:2766415
Abstract

The direct addition of levamisole to murine splenic lymphocytes had no effect on the mitogenic activity of lipopolysaccharide. However, the addition of serum of mice orally treated with levamisole increased the mitogenic activity, and this increased activity using serum was similar to the result obtained in an in vivo experiment. These results suggest that the new in vitro experimental method using serum may be able to reproduce the in vivo effect of drugs.

摘要

相似文献

1
A new pharmacological testing method--different effects of levamisole and the serum of mice orally treated with levamisole on mitogenic activity of lipopolysaccharide.
Chem Pharm Bull (Tokyo). 1989 Apr;37(4):1117-9. doi: 10.1248/cpb.37.1117.
2
Effect of shosaikoto, a Japanese and Chinese traditional herbal medicinal mixture, on the mitogenic activity of lipopolysaccharide: a new pharmacological testing method.日本和中国传统草药混合制剂小柴胡汤对脂多糖促有丝分裂活性的影响：一种新的药理学检测方法。
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LPS regulation of the immune response: separate mechanisms for murine B cell activation by lipid A (direct) and polysaccharide (macrophage-dependent) derived from Bacteroides LPS.脂多糖对免疫反应的调节：来自拟杆菌属脂多糖的脂质A（直接作用）和多糖（巨噬细胞依赖性）激活小鼠B细胞的不同机制。
J Immunol. 1984 Nov;133(5):2294-300.
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In vitro stimulation of murine lymphoid cell cultures by levamisole.左旋咪唑对小鼠淋巴细胞培养物的体外刺激作用。
Clin Exp Immunol. 1975 Dec;22(3):486-92.
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Effect of levamisole (NSC-177023) on DNA synthesis by lymphocytes from immunosuppressed C57BL mice.
Cancer Chemother Rep. 1975 May-Jun;59(3):531-6.
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Low mitogenic activity of synthetic lipid A analog, 2,3-acyloxyacylgalactosamine-4-phosphate, in cultured murine splenocytes.
Biol Pharm Bull. 1993 Feb;16(2):201-2. doi: 10.1248/bpb.16.201.
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Isolation and characterization of murine spleen cells responsive to levamisole.
Clin Immunol Immunopathol. 1978 Jan;9(1):47-54. doi: 10.1016/0090-1229(78)90119-8.
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[Effect of levamisole on the cytotoxic activity of normal lymphocytes in tissue culture].[左旋咪唑对组织培养中正常淋巴细胞细胞毒性活性的影响]
Biull Eksp Biol Med. 1979 Nov;88(11):581-2.
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[Decrease in adenylate cyclase activity in spleen T- and B-lymphocytes and thymus T-lymphocytes in CBA mice treated with levamisole].
Ukr Biokhim Zh (1978). 1988 May-Jun;60(3):89-91.
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Effect of levamisole on the in vitro immune response of spleen lymphocytes.左旋咪唑对脾淋巴细胞体外免疫反应的影响。
Proc Soc Exp Biol Med. 1975 Apr;148(4):1048-50. doi: 10.3181/00379727-148-38686.

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