Ohnishi S T, Ohnishi N, Oda Y, Katsuoka M
Membrane Research Institute, University City Science Center, Philadelphia, PA.
Cell Biochem Funct. 1989 Apr;7(2):105-9. doi: 10.1002/cbf.290070205.
New prostaglandin oligomeric derivatives, termed MR-256 and MR-356, were found to inhibit the growth of murine malarial parasites, P. chabaudi and P. vinckei, within red blood cells in vivo. When mice were infected with P. chabaudi, both MR-256 and MR-356 suppressed the growth of parasites, but MR-356 had a greater inhibitory effect than MR-256. With P. vinckei, MR-356 also inhibited the growth of parasites, and improved the survival rate. The effect of MR-256 was much less. A possible inhibitory mechanism of action of these drugs is discussed.
新的前列腺素低聚物衍生物，称为MR - 256和MR - 356，被发现可在体内抑制红细胞内的鼠疟原虫，即查巴迪疟原虫和文氏疟原虫的生长。当小鼠感染查巴迪疟原虫时，MR - 256和MR - 356均能抑制疟原虫的生长，但MR - 356的抑制作用比MR - 256更强。对于文氏疟原虫，MR - 356也能抑制疟原虫的生长，并提高存活率。MR - 256的作用则小得多。文中讨论了这些药物可能的抑制作用机制。
