Bert J L, Bowen B D, Gu X, Lund T, Reed R K
Department of Chemical Engineering, University of British Columbia, Vancouver Canada.
Circ Shock. 1989 Jul;28(3):199-219.
A mathematical model of microvascular exchange in the rat following a burn injury was developed by extending an existing model of normal microvascular exchange to include perturbations characteristic of burn injuries without fluid resuscitation. The changes anticipated for small (10% body surface area) and large (40% body surface area) burns are incorporated systematically into the model until there is no improvement in the statistical fit of the simulation predictions with the experimental data of Lund and Reed (Circulatory Shock 20:91-104, 1986). The "best fit" perturbations for the small burn include the experimentally measured changes in mean arterial pressure and injured tissue pressure as well as changes to plasma protein and fluid transport coefficients in the injured tissue. The larger burn "best fit" simulation required changes to the plasma protein transport coefficients in the intact tissues as well as all of the changes listed above. The simulation results are compared with the available experimental information on burn injuries as well as with the specific data of Lund and Reed (Circulatory Shock 20:91-104, 1986).
通过扩展现有的正常微血管交换模型，建立了大鼠烧伤后微血管交换的数学模型，以纳入未进行液体复苏的烧伤损伤的特征性扰动。小面积（10%体表面积）和大面积（40%体表面积）烧伤预期的变化被系统地纳入模型，直到模拟预测的统计拟合与Lund和Reed的实验数据（《循环休克》20:91 - 104，1986）没有进一步改善。小面积烧伤的“最佳拟合”扰动包括实验测量的平均动脉压和损伤组织压力的变化，以及损伤组织中血浆蛋白和液体转运系数的变化。大面积烧伤的“最佳拟合”模拟需要完整组织中血浆蛋白转运系数的变化以及上述所有变化。模拟结果与现有的烧伤损伤实验信息以及Lund和Reed的具体数据（《循环休克》20:91 - 104，1986）进行了比较。
