Tang C M, Huang J, Gan Y C, Wu O L, Li S L, Yao R F, Xie C D, Xie G G, He Q M, Meng R B
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1989;7(1):43-6.
From 1984-1987, mass application of mebendazole-medicated salt was studied for the control of hookworm infection in 5 pilot areas (Wuming, Shanlin, Bobai, Guilin and Rongxian Counties) in Guangxi Zhuang Autonomous Region. The dosages of mebendazole (mixed with salt) administered were 15mg, 25mg, 30mg, 40mg, 50mg, 30mg, 70mg, 80mg, 100mg or 200mg per person per day for 15, 20 or 30 days. The results showed that 40mg/day for 15-20 days could result in stool egg negative conversion rates of 92.3 to 94.4%, while 50mg/day for 30 days resulted in 96.9 to 100%. Concurrently, the hookworm infection rate in pilot areas dropped by 57.9-71.7% in a short time; whereas the stool egg negative conversion rate of Ascaris lumbricoides was as high as 99.1% to 100% at the same dosage, when the dosage of 100mg/day for 30 days was given, the egg negative reversion rate for Trichuris trichiura was 97.6%. Promising result was also recorded concerning the tolerance of the medicated salt, as the side effects in the inhabitants were mild. In conclusion, the authors considered that the application of mebendazole-medicated salt was a simple and effective measure in controlling hookworm infection, especially in the light of solving the problem of incomplete mass detection and selected mass treatment. Furthermore, it is much more economic from the cost-effect point of view.
1984年至1987年，在广西壮族自治区的5个试点地区（武鸣、山心、博白、桂林和容县）研究了大规模应用甲苯咪唑药盐控制钩虫感染的情况。所使用的甲苯咪唑（与盐混合）剂量为每人每天15毫克、25毫克、30毫克、40毫克、50毫克、30毫克、70毫克、80毫克、100毫克或200毫克，持续15、20或30天。结果显示，每天40毫克，持续15至20天，粪便虫卵阴转率可达92.3%至94.4%；而每天50毫克，持续30天，阴转率为96.9%至100%。同时，试点地区的钩虫感染率在短时间内下降了57.9%至71.7%；在相同剂量下，蛔虫的粪便虫卵阴转率高达99.1%至100%，当给予每天100毫克，持续30天的剂量时，鞭虫的虫卵阴转率为97.6%。药盐的耐受性也取得了良好结果，居民的副作用较轻。总之，作者认为应用甲苯咪唑药盐是控制钩虫感染的一种简单有效的措施，特别是在解决大规模检测不彻底和选择性群体治疗的问题方面。此外，从成本效益的角度来看，它更具经济性。
