Chen Y, Xu G, Feng Z, Guo Z, Lin J, Fang Y
Fujian Institute of Parasitic Disease, Fuzhou, China.
Southeast Asian J Trop Med Public Health. 1997 Jun;28(2):344-6.
The therapeutic effect of praziquantel and mebendazole-medicated salt has been studied in 109 cases with Echinochasmus fujianensis infection. These cases were randomly divided into four groups: 2 groups with a single dose of praziquantel 5 mg/kg or 2.5 mg/kg; and other 2 groups with mebendazole 800mg or 400 mg in 10d table salt. Four weeks after treatment, the egg negative conversion rates were 100%, 92.3%, 85.2% and 71.4% respectively, the egg reduction rates were 84.8-100%, and side-effects were mild. The symptoms caused by infection such as abdominal pain, diarrhea, distension and anorexia were obviously relieved. These data indicated that praziquantel is the drug of choice in the treatment of Echinochasmus fujianensis. The dosage is only 2.5 mg/kg, and its egg negative conversion rate and reduction rate reach 92.3% and 95.4%, respectively. For convenience, the dosage can be made according to their age. Children under 12 take half a tablet (100 mg), and one tablet (200 mg) for those over 12. This dosage is approximately equal to 2.5-5.0 mg/kg. Although the efficacy of mebendazole is lower than praziquantel, its egg negative conversion rate also reaches 71.4-85%. Mebendazole-medicated salt can be used for treating Echinochasmus fujianensis infection as the presence of co-infection with nematodes.
对109例福建棘隙吸虫感染病例研究了吡喹酮和甲苯达唑药盐的治疗效果。这些病例被随机分为四组：两组单次服用吡喹酮，剂量分别为5mg/kg或2.5mg/kg；另外两组服用甲苯达唑，剂量分别为800mg或400mg，加入10天的食盐中。治疗四周后，虫卵阴转率分别为100%、92.3%、85.2%和71.4%，虫卵减少率为84.8%-100%，且副作用轻微。由感染引起的腹痛、腹泻、腹胀和厌食等症状明显缓解。这些数据表明，吡喹酮是治疗福建棘隙吸虫的首选药物。其剂量仅为2.5mg/kg，虫卵阴转率和减少率分别达到92.3%和95.4%。为方便起见，可根据年龄调整剂量。12岁以下儿童服用半片（100mg），12岁以上服用1片（200mg）。该剂量约等于2.5-5.0mg/kg。虽然甲苯达唑的疗效低于吡喹酮，但其虫卵阴转率也达到71.4%-85%。甲苯达唑药盐可用于治疗福建棘隙吸虫感染，尤其是存在线虫混合感染的情况。
