Khusainov I, Marenna A, Cerciat M, Fechter P, Hashem Y, Marzi S, Romby P, Yusupova G, Yusupov M
IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Department of Structural Biology and Genomics, Illkirch, F-67404 France; Inserm, U596, Illkirch, F-67400 France; CNRS, UMR7104, Illkirch, F-67400 France; Université Louis Pasteur, Strasbourg, F-67000 France.
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlyovskaya St. 18, Kazan 420008, Russia.
Mol Biol (Mosk). 2016 Jul-Aug;50(4):549-557. doi: 10.7868/S0026898416040042.
Staphylococcus aureus is a major opportunistic and versatile pathogen. Because the bacteria rapidly evolve multi-resistances towards antibiotics, there is an urgent need to find novel targets and alternative strategies to cure bacterial infections. Here, we provide a brief overview on the knowledge acquired on S. aureus ribosomes, which is one of the major antibiotic targets. We will show that subtle differences exist between the translation at the initiation step of Gram-negative and Gram-positive bacteria although their ribosomes display a remarkable degree of resemblance. In addition, we will illustrate using specific examples the diversity of mechanisms controlling translation initiation in S. aureus that contribute to shape the expression of the virulence factors in a temporal and dynamic manner.
金黄色葡萄球菌是一种主要的机会性和多功能病原体。由于该细菌对抗生素迅速产生多重耐药性，因此迫切需要寻找新的靶点和替代策略来治疗细菌感染。在此，我们简要概述一下关于金黄色葡萄球菌核糖体的已有知识，核糖体是主要的抗生素靶点之一。我们将表明，尽管革兰氏阴性菌和革兰氏阳性菌的核糖体有显著的相似性，但在翻译起始步骤仍存在细微差异。此外，我们将通过具体例子说明金黄色葡萄球菌中控制翻译起始的机制多样性，这些机制有助于以时间和动态的方式塑造毒力因子的表达。
