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用于治疗听觉过敏的微创手术

Minimally Invasive Surgery for the Treatment of Hyperacusis.

作者信息

Silverstein Herbert, Ojo Rosemary, Daugherty Julie, Nazarian Ronen, Wazen Jack

机构信息

*Ear Research Foundation, Sarasota, Florida†Osborne Head & Neck Institute, Cedar Sinai Medical Center, Los Angeles, California.

出版信息

Otol Neurotol. 2016 Dec;37(10):1482-1488. doi: 10.1097/MAO.0000000000001214.

DOI:10.1097/MAO.0000000000001214
PMID:27668792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5100801/
Abstract

OBJECTIVE

To evaluate the efficacy of a minimally invasive surgical procedure in patients with severe hyperacusis.

STUDY DESIGN

Prospective, longitudinal design.

SETTING

Tertiary referral center.

PATIENTS

Adult patients with history of severe hyperacusis.

INTERVENTION

Using a transcanal approach, the round and oval window was reinforced with temporalis fascia or tragal perichondrium in six subjects (nine ears) and was subdivided into two groups (unilateral or bilateral reinforcement procedure).

MAIN OUTCOME MEASURES

Pre- and postoperative noise tolerance was measured using uncomfortable loudness level (ULL) test scores. In addition, a self-report hyperacusis questionnaire (HQ) was used to assess hypersensitivity to sound before and after the intervention.

RESULTS

Analysis of the data reveals improved postoperative mean ULL test scores of 14 dB (confidence interval [CI], 70-98 dB) in the unilateral group. For the bilateral group, improved mean scores were 13 dB (CI, 63-88 dB) in the first ear and 8 dB (CI, 71-86 dB) for the second ear. Further, a negative linear trend was observed in the mean subjective scores for the HQ when both groups measures were analyzed together decreasing from a mean score of 32.0 (standard deviation [SD] = 3.32) preoperative to a mean score of 11.5 (SD = 7.42) after surgery. Postoperatively, the patients reported no change in hearing and improved quality of life after the procedure.

CONCLUSION

The results suggest that reinforcement of the round and oval window with temporalis fascia or tragal perichondrium may offer significant benefit for individuals with severe hyperacusis that has not responded to traditional therapy. ULL scores and self-report measures postoperatively demonstrate improved noise tolerance, high patient satisfaction, and enhanced quality of life.

摘要

目的

评估一种微创手术对重度听觉过敏患者的疗效。

研究设计

前瞻性纵向设计。

研究地点

三级转诊中心。

患者

有重度听觉过敏病史的成年患者。

干预措施

采用经耳道入路,对6名受试者(9只耳)的圆窗和卵圆窗用颞肌筋膜或耳屏软骨膜进行加固,并分为两组(单侧或双侧加固手术)。

主要观察指标

使用不舒适响度级(ULL)测试分数测量术前和术后的噪声耐受性。此外,使用听觉过敏自评问卷(HQ)评估干预前后对声音的超敏反应。

结果

数据分析显示,单侧组术后平均ULL测试分数提高了14dB(置信区间[CI],70 - 98dB)。双侧组中,第一只耳平均分数提高了13dB(CI,63 - 88dB),第二只耳提高了8dB(CI,71 - 86dB)。此外,当对两组测量结果进行综合分析时,HQ的平均主观分数呈负线性趋势,从术前的平均分数32.0(标准差[SD]=3.32)降至术后的平均分数11.5(SD=7.42)。术后,患者报告听力无变化,术后生活质量有所改善。

结论

结果表明,用颞肌筋膜或耳屏软骨膜加固圆窗和卵圆窗可能对传统治疗无效的重度听觉过敏患者有显著益处。术后ULL分数和自评指标显示噪声耐受性提高、患者满意度高且生活质量得到改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/5100801/493b6aee4b33/mao-37-1482-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/5100801/1b99f8ded2ef/mao-37-1482-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/5100801/0d3e60547b0a/mao-37-1482-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/5100801/d5638a200058/mao-37-1482-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/5100801/3ab8345adb8f/mao-37-1482-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/5100801/493b6aee4b33/mao-37-1482-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/5100801/1b99f8ded2ef/mao-37-1482-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/5100801/0d3e60547b0a/mao-37-1482-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/5100801/d5638a200058/mao-37-1482-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/5100801/3ab8345adb8f/mao-37-1482-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/5100801/493b6aee4b33/mao-37-1482-g005.jpg

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Front Neurol. 2015 May 15;6:105. doi: 10.3389/fneur.2015.00105. eCollection 2015.
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