a Department of Geriatric Cardiology , Chinese People's Liberation Army (PLA) General Hospital & Medical School of Chinese PLA , Beijing , China.
b Department of Cadre Clinic , Chinese PLA General Hospital & Medical School of Chinese PLA , Beijing , China.
Clin Exp Hypertens. 2016;38(7):618-623. doi: 10.1080/10641963.2016.1182177. Epub 2016 Sep 26.
BACKGROUND/OBJECTIVES: Our study aimed to explore whether the ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) were associated with albuminuria in community-based Han Chinese. METHODS: Total 2127 subjects (860 men and 1267 women) aged 60 years and over were recruited in Beijing. Albuminuria was assessed by the urinary albumin-to-creatinine ratio (UACR) of ≥30 mg/g. BaPWV was divided by quartile. The logistic regression was used to determine the odds ratio (OR) and 95% confidence intervals (CIs) of ABI and baPWV with albuminuria. RESULTS: ABI was associated with albuminuria in the interaction model (OR 0.89, 95% CI 0.81-0.99 by every 0.1 unit increase of ABI), especially in hypertension (OR 0.82, 95% CI 0.73-0.92) and diabetes (OR 0.83, 95% CI 0.68-0.98) groups. BaPWV groups were also significantly associated with albuminuria, ORs of having albuminuria for baPWV quartile II, III, and IV were 1.02(0.65-1.52), 1.05(0.72-1.61), and 1.18(1.04-1.47) in the interaction model. For hypertension and diabetes patients, only the baPWV quartile IV group had higher OR. CONCLUSIONS: ABI and baPWV were associated with albuminuria after adjusting for other risk factors in Chinese community-based elderly Han population. The association of ABI with albuminuria was stronger in hypertension and diabetes patients.
背景/目的:本研究旨在探讨踝臂指数(ABI)和臂踝脉搏波速度(baPWV)与汉族社区人群白蛋白尿的关系。
方法:共纳入北京 2127 名年龄在 60 岁及以上的受试者(男 860 名,女 1267 名)。白蛋白尿通过尿白蛋白与肌酐比值(UACR)≥30mg/g 进行评估。baPWV 按四分位法分组。采用 logistic 回归分析 ABI 和 baPWV 与白蛋白尿的比值比(OR)及其 95%置信区间(CI)。
结果:ABI 与交互模型中的白蛋白尿相关(ABI 每增加 0.1 单位,OR 0.89,95%CI 0.81-0.99),尤其是在高血压(OR 0.82,95%CI 0.73-0.92)和糖尿病(OR 0.83,95%CI 0.68-0.98)组。baPWV 各组与白蛋白尿也有显著相关性,baPWV 四分位 II、III 和 IV 组发生白蛋白尿的 OR 分别为 1.02(0.65-1.52)、1.05(0.72-1.61)和 1.18(1.04-1.47)。对于高血压和糖尿病患者,只有 baPWV 四分位 IV 组的 OR 更高。
结论:在中国汉族社区老年人群中,ABI 和 baPWV 在调整其他危险因素后与白蛋白尿相关。ABI 与白蛋白尿的相关性在高血压和糖尿病患者中更强。
Zhonghua Xin Xue Guan Bing Za Zhi. 2015-4
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