Department of Cardiology, Peking University First Hospital, Beijing, People's Republic of China.
Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, People's Republic of China.
J Hum Hypertens. 2023 May;37(5):412-418. doi: 10.1038/s41371-022-00697-7. Epub 2022 Apr 26.
This study was performed to investigate and compare the association of albuminuria with the brachial-ankle pulse wave velocity (baPWV) and carotid-femoral pulse wave velocity (cfPWV) in a community-based population in Beijing. Subjects were enrolled from a follow-up survey conducted in 2018 from an atherosclerosis cohort in Shijingshan district, Beijing, China. The baPWV and cfPWV were measured using a BP-203 RPE III arteriosclerosis detection device and PulsePen, respectively. Albuminuria was defined as a urinary albumin-creatinine ratio of ≥30 mg/g. A multivariate logistic regression model was used to evaluate the impacts of different PWV measurements on the prevalence of albuminuria. In total, 5605 subjects were included in the analyses. Their mean age was 62.22 ± 7.55 years, and the prevalence of albuminuria was 8.22%. In the multivariate logistic regression model adjusted for potential covariates, both baPWV (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.03-1.10; P < 0.001) and cfPWV (OR, 1.07; 95% CI, 1.01-1.14; P = 0.018) were significantly associated with albuminuria. Furthermore, when baPWV and cfPWV were entered into the logistic regression model simultaneously, only baPWV was significantly associated with albuminuria using either continuous value (OR, 1.05; 95% CI, 1.01-1.10; P = 0.007) or classified into quartiles (highest vs. lowest value group: OR, 1.55; 95% CI, 1.01-2.37; P for trend = 0.019). Both cfPWV and baPWV were positively associated with albuminuria, while baPWV had a stronger relationship than cfPWV. Thus, baPWV measurement could be considered for the purpose of community health screening.
本研究旨在探讨和比较白蛋白尿与肱踝脉搏波速度（baPWV）和颈股脉搏波速度（cfPWV）在北京市社区人群中的相关性。研究对象来自于中国北京市石景山区动脉粥样硬化队列的 2018 年随访调查。baPWV 和 cfPWV 分别使用 BP-203 RPE III 动脉硬化检测仪和 PulsePen 进行测量。白蛋白尿定义为尿白蛋白/肌酐比值≥30mg/g。采用多变量 logistic 回归模型评估不同 PWV 测量值对白蛋白尿患病率的影响。共纳入 5605 名受试者进行分析。他们的平均年龄为 62.22±7.55 岁，白蛋白尿的患病率为 8.22%。在调整了潜在混杂因素的多变量 logistic 回归模型中，baPWV（比值比 [OR]，1.06；95%置信区间 [CI]，1.03-1.10；P<0.001）和 cfPWV（OR，1.07；95%CI，1.01-1.14；P=0.018）均与白蛋白尿显著相关。此外，当将 baPWV 和 cfPWV 同时纳入 logistic 回归模型时，仅 baPWV 与白蛋白尿显著相关，无论是连续值（OR，1.05；95%CI，1.01-1.10；P=0.007）还是分为四等份（最高值与最低值组：OR，1.55；95%CI，1.01-2.37；P 趋势=0.019）。cfPWV 和 baPWV 均与白蛋白尿呈正相关，而 baPWV 与白蛋白尿的相关性强于 cfPWV。因此，baPWV 测量可用于社区健康筛查。
