Hong J L, Xu C L, Ju H M
Zhonghua Xin Xue Guan Bing Za Zhi. 1989 Feb;17(1):42-4, 63.
The effects of dietary cholesterol on plasma Apo B-containing lipoprotein was studied in 18 rabbits. When atherosclerosis was induced by dietary cholesterol, the cholesterol and peroxide lipids were increased in the intima of aortae (P less than 0.05). The increased plasma Apo B was positively correlated with hypercholesterolemia (r = 0.879, P less than 0.005). In the pre-stain lipoprotein electrophoresis and immunoelectrophoresis with Apo B antiserum, electrophoretic mobility of Apo B-containing lipoprotein was slower than those of the control rabbits and this band was wide and stained deeper. In Sephadex G-200 exclusion chromatography there was evidence showing that the reduction in electrophoretic mobility of Apo B-containing lipoprotein is due to the increase particle size.
在18只兔子身上研究了膳食胆固醇对血浆含载脂蛋白B（Apo B）脂蛋白的影响。当通过膳食胆固醇诱导动脉粥样硬化时，主动脉内膜中的胆固醇和过氧化脂质增加（P<0.05）。血浆Apo B升高与高胆固醇血症呈正相关（r = 0.879，P<0.005）。在预染脂蛋白电泳和用Apo B抗血清进行的免疫电泳中，含Apo B脂蛋白的电泳迁移率比对照兔慢，且该条带较宽且染色更深。在葡聚糖凝胶G-200排阻色谱中，有证据表明含Apo B脂蛋白电泳迁移率降低是由于颗粒大小增加所致。
