de Arcos F, Castelo-Branco C, Casals E, Sanllehy C, Cararach V
Department of Obstetrics and Gynecology, Hospital Clinic, University of Barcelona, Spain.
J Reprod Med. 1998 Feb;43(2):144-8.
To evaluate plasma lipids, lipoproteins and apolipoprotein changes induced by gestational diabetes.
In this case-control study, 60 women between 26 and 32 weeks of pregnancy were allocated to four groups according to lipid status and glucose tolerance: (1) normolipemia and no gestational diabetes, (2) normolipemia and gestational diabetes, (3) hyperlipemia and no gestational diabetes, and (4) hyperlipemia and gestational diabetes. Total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, very low density lipoprotein cholesterol (VLDLc), triglycerides, triglycerides/very low density lipoprotein (VLDL), apolipoproteins (APO) A1 and APO B, APO B-VLDL and APO B/low-density lipoprotein were measured.
There were no statistically significant differences in the normolipemic group of women. Among the hyperlipemic patients, gestational diabetic women showed lower VLDLc when compared to nondiabetic patients.
Our results, comparing groups separated groups by lipid status, show that the only difference in lipid profile associated with glucose intolerance is lower VLDLc in hyperlipemic patients.
评估妊娠期糖尿病引起的血浆脂质、脂蛋白和载脂蛋白变化。
在这项病例对照研究中，60名孕26至32周的女性根据脂质状态和糖耐量被分为四组：（1）血脂正常且无妊娠期糖尿病，（2）血脂正常且有妊娠期糖尿病，（3）高脂血症且无妊娠期糖尿病，（4）高脂血症且有妊娠期糖尿病。测量了总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇（VLDLc）、甘油三酯、甘油三酯/极低密度脂蛋白（VLDL）、载脂蛋白（APO）A1和APO B、APO B-VLDL以及APO B/低密度脂蛋白。
血脂正常组女性之间无统计学显著差异。在高脂血症患者中，与非糖尿病患者相比，妊娠期糖尿病女性的VLDLc较低。
我们按脂质状态分组进行比较的结果表明，与糖耐量异常相关的脂质谱唯一差异是高脂血症患者的VLDLc较低。
