Pozzi Nicolò G, Arnulfo Gabriele, Canessa Andrea, Steigerwald Frank, Nickl Robert, Homola György A, Fato Marco M, Matthies Cordula, Pacchetti Claudio, Volkmann Jens, Isaias Ioannis U
Department of Neurology of the University Hospital Wuerzburg and Julius-Maximilians-University, 97080 Wuerzburg, Germany.
Department of Neurology of the University Hospital Wuerzburg and Julius-Maximilians-University, 97080 Wuerzburg, Germany.
Clin Neurophysiol. 2016 Nov;127(11):3387-3393. doi: 10.1016/j.clinph.2016.09.004. Epub 2016 Sep 10.
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established treatment for Parkinson's disease (PD). Anatomical connectivity analyses and task-related physiological studies have divided the STN into different functional domains: sensorimotor, limbic, and associative - located in its dorsolateral (dSTN), anteroventral (vSTN) and medial territories, respectively. Targeting sensorimotor STN is essential for stimulation efficacy and is supported by intraoperative micro-electrode recordings. A different neuronal signature in microelectrode recordings across STN subterritories was explored in this study.
Stable recordings from 30 PD patients were assigned to dSTN or vSTN by means of an anatomical method (based on fused computed tomography/magnetic resonance images) and through a priori tri-segmented partition of the recording itself. We computed the inter-spike interval (ISI) and ISI-characteristics, mean firing rate (MFR), discharge patterns and mean burst rate (MBR) of each detected single unit activity.
We showed a different MBR between dSTN and vSTN (1.51±0.18 vs. 1.76±0.22events/minute, Wilcoxon rank sum test, p<0.05) and a trend in the difference between their MFR (12.78 vs. 15.05Hz, Wilcoxon rank sum test, p=0.053) only with the anatomically based method.
Burst firing differs across STN subterritories.
Different functions of subthalamic domains might be reflected by distinctive burst signalling of its subterritories.
丘脑底核深部脑刺激术（STN-DBS）是帕金森病（PD）的一种既定治疗方法。解剖学连通性分析和与任务相关的生理学研究已将丘脑底核分为不同的功能域：感觉运动、边缘和联合功能域，分别位于其背外侧（dSTN）、腹前侧（vSTN）和内侧区域。靶向感觉运动丘脑底核对于刺激效果至关重要，术中微电极记录对此提供了支持。本研究探索了丘脑底核不同亚区域微电极记录中不同的神经元特征。
通过解剖学方法（基于融合计算机断层扫描/磁共振图像）并通过对记录本身进行先验的三段划分，将30例帕金森病患者的稳定记录分配到背外侧丘脑底核或腹前侧丘脑底核。我们计算了每个检测到的单个单位活动的峰间间隔（ISI）及其特征、平均放电率（MFR）、放电模式和平均爆发率（MBR）。
仅采用基于解剖学的方法时，我们发现背外侧丘脑底核和腹前侧丘脑底核之间的平均爆发率存在差异（1.51±0.18对1.76±0.22次/分钟，Wilcoxon秩和检验，p<0.05），且它们的平均放电率也有差异趋势（12.78对15.05Hz，Wilcoxon秩和检验，p = 0.053）。
丘脑底核不同亚区域的爆发式放电有所不同。
丘脑底核不同区域的不同功能可能由其亚区域独特的爆发信号所反映。
