γ-乙烯基氨基丁酸和卡马西平的电生理效应

Electrophysiologic effects of gamma-vinyl GABA and carbamazepine.

作者信息

Mervaala E, Partanen J, Nousianinen U, Sivenius J, Riekkinen P

机构信息

Department of Clinical Neurophysiology, Vaajasalo Epilepsy Hospital, Kortejoki, Finland.

出版信息

Epilepsia. 1989 Mar-Apr;30(2):189-93. doi: 10.1111/j.1528-1157.1989.tb05453.x.

DOI:10.1111/j.1528-1157.1989.tb05453.x

PMID:2924744

Abstract

The effects of gamma-vinyl GABA (GVG) and carbamazepine (CBZ) monotherapy on somatosensory (SEP) and visual (VEP) evoked potentials and spectral quantitative EEG (QEEG) were studied in 17 patients with complex partial seizures using a cross-over double-blind study design. CBZ was associated with statistically significant prolongation of SEP latencies. When the drug was switched to GVG, shortening of the peak latencies was observed. Prolonged pattern-VEP peaks were observed both during CBZ and GVG monotherapies. A similar but more subtle tendency of the peaks was observed in P100 latencies. Spectral EEG revealed a slowing of the occipital rhythm with CBZ. No QEEG changes related to GVG were found. The use of multimodal evoked potentials and QEEG should be considered in studying the effects of new antiepileptic drugs (AEDs).

摘要

采用交叉双盲研究设计，对17例复杂部分性发作患者进行了γ-乙烯基氨基丁酸（GVG）和卡马西平（CBZ）单药治疗对体感诱发电位（SEP）、视觉诱发电位（VEP）及频谱定量脑电图（QEEG）影响的研究。CBZ与SEP潜伏期在统计学上显著延长相关。当药物换为GVG时，观察到峰潜伏期缩短。在CBZ和GVG单药治疗期间均观察到图形VEP峰延长。在P100潜伏期观察到类似但更细微的峰变化趋势。频谱脑电图显示CBZ使枕区节律减慢。未发现与GVG相关的QEEG变化。在研究新型抗癫痫药物（AEDs）的作用时，应考虑使用多模式诱发电位和QEEG。