含有（2,3-f）吡嗪并（1,10）菲咯啉-2,3-二羧酸作为多供体配体的新型单核铂和钯配合物。合成、结构、与DNA的相互作用、体外细胞毒性及细胞凋亡
Novel mononuclear Pt and Pd complexes containing (2,3-f)pyrazino(1,10)phenanthroline-2,3-dicarboxylic acid as a multi-donor ligand. Synthesis, structure, interaction with DNA, in vitro cytotoxicity, and apoptosis.
作者信息
Sun Ya-Guang, Sun Yi-Ning, You Li-Xin, Liu Yi-Nan, Ding Fu, Ren Bao-Yi, Xiong Gang, Dragutan Valerian, Dragutan Ileana
机构信息
The Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China.
The Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China.
出版信息
J Inorg Biochem. 2016 Nov;164:129-140. doi: 10.1016/j.jinorgbio.2016.09.008. Epub 2016 Sep 14.
New cytotoxic, mononuclear Pt and Pd coordination complexes featuring the planar, multi-donor ligand (2,3-f)pyrazino(1,10)phenanthroline-2,3-dicarboxylic acid (HPPDA) have been synthesized under hydrothermal conditions (in water, at high temperature and pressure) and fully characterized. The complexes were proven to be isostructural by applying the single-crystal X-ray diffraction technique. UV-Vis and fluorescence spectroscopy investigations on their interaction with fish sperm DNA revealed a considerable binding capacity while gel electrophoresis provided evidence in favor of cleavage of pBR322 plasmid DNA. The newly synthesized complexes manifested significant in vitro cytotoxic activity against two different human cancer cell lines, the KB and JEKO cells, with cell death mainly caused by apoptosis.
在水热条件下（在水中，高温高压）合成了具有平面多供体配体（2,3-f）吡嗪并（1,10）菲咯啉-2,3-二羧酸（HPPDA）的新型细胞毒性单核铂和钯配位络合物，并对其进行了全面表征。通过单晶X射线衍射技术证明这些络合物是同构的。对它们与鱼精子DNA相互作用的紫外可见光谱和荧光光谱研究表明它们具有相当大的结合能力，而凝胶电泳提供了支持pBR322质粒DNA裂解的证据。新合成的络合物对两种不同的人类癌细胞系KB和JEKO细胞表现出显著的体外细胞毒性活性，细胞死亡主要由凋亡引起。
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